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dc.creatorHadjigeorgiou G.F., Singh R., Dardiotis E., Paterakis K., Hadjigeorgiou G.M., Fountas K.N.en
dc.date.accessioned2023-01-31T08:27:25Z
dc.date.available2023-01-31T08:27:25Z
dc.date.issued2017
dc.identifier10.23736/s0390-5616.16.03589-X
dc.identifier.issn03905616
dc.identifier.urihttp://hdl.handle.net/11615/73759
dc.description.abstractTraumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Identification of endogenous neuroprotective mechanisms after TBI and the development of therapeutic targets to improve TBI outcomes are areas of intense scientific research. In this review, we summarize genetically modified TBI mouse models and highlight the recent scientific findings from using such models, including mediators of inflammation, programmed cell death and metabolism, modulators of vascular tone and membrane channel proteins. A deeper understanding of the complex biochemical processes and genetic pathways in TBi could offer personalized genomic-based therapies for and improve clinical outcomes in TBI patients. © 2016 Edizioni Minerva Medica.en
dc.language.isoenen
dc.sourceJournal of Neurosurgical Sciencesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031320074&doi=10.23736%2fs0390-5616.16.03589-X&partnerID=40&md5=45cad54bea90189143efcfd8595f6847
dc.subjectadenosine A1 receptoren
dc.subjectadenosine A2 receptoren
dc.subjectamyloid precursor proteinen
dc.subjectbradykinin B1 receptoren
dc.subjectbradykinin B2 receptoren
dc.subjectcalpain 1en
dc.subjectchemokine receptor CXCR2en
dc.subjectcyclooxygenase 1en
dc.subjectfibronectinen
dc.subjectheat shock proteinen
dc.subjectintercellular adhesion molecule 2en
dc.subjectinterleukin 6en
dc.subjectneurotrophinen
dc.subjectprotein bcl 2en
dc.subjecttumor necrosis factoren
dc.subjectanimal cellen
dc.subjectanimal modelen
dc.subjectgene inactivationen
dc.subjectmouseen
dc.subjectneuroprotectionen
dc.subjectnonhumanen
dc.subjectReviewen
dc.subjecttraumatic brain injuryen
dc.subjecttumor suppressor geneen
dc.subjectanimalen
dc.subjectdisease modelen
dc.subjectgene knockouten
dc.subjectknockout mouseen
dc.subjecttraumatic brain injuryen
dc.subjectAnimalsen
dc.subjectBrain Injuries, Traumaticen
dc.subjectDisease Models, Animalen
dc.subjectGene Knockout Techniquesen
dc.subjectMice, Knockouten
dc.subjectEdizioni Minerva Medicaen
dc.titleTraumatic brain injury and gene knockout animal models: An up-to-date reviewen
dc.typeotheren


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