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The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders

dc.creatorDionysopoulou S., Charmandari E., Bargiota A., Vlachos N., Mastorakos G., Valsamakis G.en
dc.date.accessioned2023-01-31T07:57:11Z
dc.date.available2023-01-31T07:57:11Z
dc.date.issued2021
dc.identifier10.3390/nu13020498
dc.identifier.issn20726643
dc.identifier.urihttp://hdl.handle.net/11615/73375
dc.description.abstractObesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.sourceNutrientsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85100241590&doi=10.3390%2fnu13020498&partnerID=40&md5=4e691078bf5c619e2017bd6408cc3568
dc.subjectglucagon like peptide 1 receptor agonisten
dc.subjectglucagon like peptide receptoren
dc.subjectcognitive defecten
dc.subjectdiet-induced obesityen
dc.subjectdisease associationen
dc.subjectexerciseen
dc.subjecthealthy dieten
dc.subjecthumanen
dc.subjecthypothalamusen
dc.subjecthypothalamus hypophysis adrenal systemen
dc.subjectmonoaminergic systemen
dc.subjectmood disorderen
dc.subjectnervous system inflammationen
dc.subjectnonhumanen
dc.subjectpathophysiologyen
dc.subjectReviewen
dc.subjectsignal transductionen
dc.subjectsystematic reviewen
dc.subjectadverse eventen
dc.subjectanimalen
dc.subjectcognitive defecten
dc.subjectcomplicationen
dc.subjectdieten
dc.subjecthypophysis adrenal systemen
dc.subjecthypothalamus diseaseen
dc.subjecthypothalamus hypophysis systemen
dc.subjectinflammationen
dc.subjectmood disorderen
dc.subjectobesityen
dc.subjectAnimalsen
dc.subjectCognition Disordersen
dc.subjectDieten
dc.subjectDiet, Healthyen
dc.subjectExerciseen
dc.subjectGlucagon-Like Peptide Receptorsen
dc.subjectHumansen
dc.subjectHypothalamic Diseasesen
dc.subjectHypothalamo-Hypophyseal Systemen
dc.subjectInflammationen
dc.subjectMood Disordersen
dc.subjectObesityen
dc.subjectPituitary-Adrenal Systemen
dc.subjectMDPI AGen
dc.titleThe role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disordersen
dc.typeotheren


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