| dc.creator | Dimopoulou A., Manta S., Parmenopoulou V., Kollatos N., Christidou O., Triantakonstanti V.V., Schols D., Komiotis D. | en |
| dc.date.accessioned | 2023-01-31T07:56:35Z | |
| dc.date.available | 2023-01-31T07:56:35Z | |
| dc.date.issued | 2015 | |
| dc.identifier | 10.3389/fchem.2015.00021 | |
| dc.identifier.issn | 22962646 | |
| dc.identifier.uri | http://hdl.handle.net/11615/73350 | |
| dc.description.abstract | We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells. © 2015 Dimopoulou, Manta, Parmenopoulou, Kollatos, Christidou, Triantakonstanti, Schols and Komiotis. | en |
| dc.language.iso | en | en |
| dc.source | Frontiers in Chemistry | en |
| dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969174858&doi=10.3389%2ffchem.2015.00021&partnerID=40&md5=a885c0364d64b79089de76e787c8f69f | |
| dc.subject | Frontiers Media S. A | en |
| dc.title | An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents | en |
| dc.type | journalArticle | en |