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An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

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Author
Dimopoulou A., Manta S., Parmenopoulou V., Kollatos N., Christidou O., Triantakonstanti V.V., Schols D., Komiotis D.
Date
2015
Language
en
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Abstract
We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells. © 2015 Dimopoulou, Manta, Parmenopoulou, Kollatos, Christidou, Triantakonstanti, Schols and Komiotis.
URI
http://hdl.handle.net/11615/73350
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