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The Niche of n-of-1 Trials in Precision Medicine for Weight Loss and Obesity Treatment: Back to the Future
dc.creator | Grammatikopoulou M.G., Gkouskou K.K., Gkiouras K., Bogdanos D.P., Eliopoulos A.G., Goulis D.G. | en |
dc.date.accessioned | 2023-01-31T07:44:37Z | |
dc.date.available | 2023-01-31T07:44:37Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1007/s13668-022-00404-5 | |
dc.identifier.issn | 21613311 | |
dc.identifier.uri | http://hdl.handle.net/11615/72721 | |
dc.description.abstract | Purpose of Review: The n-of-1 clinical trials are considered the epitome of individualized health care. They are employed to address differences in treatment response and adverse events between patients, in a comparative effectiveness manner, extending beyond the delivery of horizontal recommendations for all. Recent Findings: The n-of-1 design has been applied to deliver precision exercise interventions, through eHealth and mHealth technologies. Regarding personalized and precision medical nutrition therapy, few trials have implemented dietary manipulations and one series of n-of-1 trials has applied comprehensive genetic data to improve body weight. With regard to anti-obesity medication, pharmacogenetic data could be applied using the n-of-1 trial design, although none have been implemented yet. Summary: The n-of-1 clinical trials consist of the only tool for the delivery of evidence-based, personalized obesity treatment (lifestyle and pharmacotherapy), reducing non-responders, while tailoring the best intervention to each patient, through “trial and error”. Their application is expected to improve obesity treatment and mitigate the epidemic. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | en |
dc.language.iso | en | en |
dc.source | Current Nutrition Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124845995&doi=10.1007%2fs13668-022-00404-5&partnerID=40&md5=51aef8628b7b2bb73c18f0b7c841940f | |
dc.subject | adverse event | en |
dc.subject | antiobesity activity | en |
dc.subject | autoregulation | en |
dc.subject | behavior change | en |
dc.subject | blood glucose monitoring | en |
dc.subject | blood pressure | en |
dc.subject | body composition | en |
dc.subject | body weight | en |
dc.subject | body weight gain | en |
dc.subject | body weight loss | en |
dc.subject | caloric intake | en |
dc.subject | clinical trial (topic) | en |
dc.subject | comparative effectiveness | en |
dc.subject | decision making | en |
dc.subject | diabetes mellitus | en |
dc.subject | diet supplementation | en |
dc.subject | evidence based practice center | en |
dc.subject | exercise | en |
dc.subject | glucose blood level | en |
dc.subject | health care management | en |
dc.subject | health care personnel | en |
dc.subject | health care system | en |
dc.subject | health service | en |
dc.subject | hemophilia | en |
dc.subject | human | en |
dc.subject | lifestyle modification | en |
dc.subject | lipid diet | en |
dc.subject | macronutrient intake | en |
dc.subject | metabolic equivalent | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | nutrigenetics | en |
dc.subject | obesity | en |
dc.subject | patient care | en |
dc.subject | patient compliance | en |
dc.subject | patient satisfaction | en |
dc.subject | patient-reported outcome | en |
dc.subject | personalized medicine | en |
dc.subject | physical activity | en |
dc.subject | practice guideline | en |
dc.subject | Review | en |
dc.subject | self monitoring | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | social media | en |
dc.subject | telehealth | en |
dc.subject | treatment response | en |
dc.subject | vegan diet | en |
dc.subject | visual analog scale | en |
dc.subject | waist circumference | en |
dc.subject | waist hip ratio | en |
dc.subject | lifestyle | en |
dc.subject | obesity | en |
dc.subject | Body Weight | en |
dc.subject | Humans | en |
dc.subject | Life Style | en |
dc.subject | Obesity | en |
dc.subject | Precision Medicine | en |
dc.subject | Weight Loss | en |
dc.subject | Springer | en |
dc.title | The Niche of n-of-1 Trials in Precision Medicine for Weight Loss and Obesity Treatment: Back to the Future | en |
dc.type | other | en |
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