dc.creator | Chatzi M., Papanikolaou J., Makris D., Papathanasiou I., Tsezou A., Karvouniaris M., Zakynthinos E. | en |
dc.date.accessioned | 2023-01-31T07:43:40Z | |
dc.date.available | 2023-01-31T07:43:40Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.1016/j.jcrc.2018.05.012 | |
dc.identifier.issn | 08839441 | |
dc.identifier.uri | http://hdl.handle.net/11615/72589 | |
dc.description.abstract | Purpose: To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. Materials and methods: The incidence of TLR2-Arg753Gln, TLR4-Asp299Gly, TLR4-Thr399Ile and TLR9-T1237C polymorphisms, and their association with ICU-acquired infections and patients' clinical outcomes were prospectively evaluated The examined genetic polymorphisms were assessed by real-time Polymerase-Chain-Reaction (PCR). Results: During a 15-month period, 224 patients were enrolled and genotyped. The prevalence of genetic polymorphisms for TLR4-Asp299Gly, TLR4-Thr399Ile, mixed TLR4-Asp299Gly/Thr399Ile, TLR9-T1237C and TLR2-Arg753Gln was 14.4%, 14.7%, 11.2%, 24.5% and 2.2%, respectively. TLR4 polymorphisms were associated with increased susceptibility towards specific ICU-acquired infections, i.e. Gram-negative central-nervous-system infections (CNSI), ventilator-associated pneumonia (VAP) and urinary-tract infections (UTI), principally due to multi-drug resistant (MDR) Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia, respectively (all P < 0.05). TLR9-T1237C polymorphism was associated with lower incidence and fewer relapses of CNSIs and UTIs when compared to mixed TLR4-Asp299Gly/Thr399Ile polymorphism group (P ≤ 0.039). ICU-stay was significantly prolonged in TLR4 polymorphisms (P ≤ 0.0416). Conclusions: Common TLR-signaling polymorphisms might be implicated in the clinical phenotype of ICU-acquired infections in Central Greece. The possible impact of TLR4 polymorphisms on enhanced susceptibility towards Gram-negative MDR-infections in defined critical-disease states warrants further investigation. Trial Registration Clinical Trials.gov identifier: NCT00932243 © 2018 | en |
dc.language.iso | en | en |
dc.source | Journal of Critical Care | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048478993&doi=10.1016%2fj.jcrc.2018.05.012&partnerID=40&md5=1eb237fc58c69bdd97c5754ddf4cb084 | |
dc.subject | toll like receptor 2 | en |
dc.subject | toll like receptor 4 | en |
dc.subject | toll like receptor 9 | en |
dc.subject | toll like receptor | en |
dc.subject | toll like receptor 2 | en |
dc.subject | toll like receptor 4 | en |
dc.subject | toll like receptor 9 | en |
dc.subject | Acinetobacter baumannii | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | bacterium detection | en |
dc.subject | central nervous system infection | en |
dc.subject | controlled study | en |
dc.subject | cytokine production | en |
dc.subject | female | en |
dc.subject | gene frequency | en |
dc.subject | gene function | en |
dc.subject | gene identification | en |
dc.subject | genetic association | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic risk | en |
dc.subject | genetic susceptibility | en |
dc.subject | genotype | en |
dc.subject | Gram negative infection | en |
dc.subject | Greece | en |
dc.subject | high risk population | en |
dc.subject | hospital infection | en |
dc.subject | human | en |
dc.subject | infection risk | en |
dc.subject | intensive care unit | en |
dc.subject | Klebsiella pneumoniae | en |
dc.subject | length of stay | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | multidrug resistance | en |
dc.subject | observational study | en |
dc.subject | predictive value | en |
dc.subject | prognosis | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | real time polymerase chain reaction | en |
dc.subject | risk assessment | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | TLR2 gene | en |
dc.subject | TLR4 gene | en |
dc.subject | TLR9 gene | en |
dc.subject | urinary tract infection | en |
dc.subject | ventilator associated pneumonia | en |
dc.subject | cross infection | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | incidence | en |
dc.subject | prevalence | en |
dc.subject | prospective study | en |
dc.subject | Cross Infection | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Incidence | en |
dc.subject | Intensive Care Units | en |
dc.subject | Length of Stay | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Prevalence | en |
dc.subject | Prospective Studies | en |
dc.subject | Real-Time Polymerase Chain Reaction | en |
dc.subject | Toll-Like Receptor 2 | en |
dc.subject | Toll-Like Receptor 4 | en |
dc.subject | Toll-Like Receptor 9 | en |
dc.subject | Toll-Like Receptors | en |
dc.subject | W.B. Saunders | en |
dc.title | Toll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece | en |
dc.type | journalArticle | en |