dc.creator | Georgitsi M.D., Vitoros V., Panou C., Tsangaris I., Aimoniotou E., Gatselis N.K., Chasou E., Kouliatsis G., Leventogiannis K., Velissaris D., Belesiotou E., Dioritou-Aggaliadou O., Giannitsioti E., Netea M.G., Giamarellos-Bourboulis E.J., Giannikopoulos G., Alexiou Z., Voloudakis N., Koutsoukou A. | en |
dc.date.accessioned | 2023-01-31T07:40:57Z | |
dc.date.available | 2023-01-31T07:40:57Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1007/s10096-015-2571-y | |
dc.identifier.issn | 09349723 | |
dc.identifier.uri | http://hdl.handle.net/11615/72176 | |
dc.description.abstract | Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. © 2016, Springer-Verlag Berlin Heidelberg. | en |
dc.language.iso | en | en |
dc.source | European Journal of Clinical Microbiology and Infectious Diseases | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954307553&doi=10.1007%2fs10096-015-2571-y&partnerID=40&md5=e263eb5ac2e4752d3e0da249c44bd3bb | |
dc.subject | interleukin 8 | en |
dc.subject | interleukin 8 | en |
dc.subject | abdominal infection | en |
dc.subject | acute pyelonephritis | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | allele | en |
dc.subject | APACHE | en |
dc.subject | Article | en |
dc.subject | bacteremia | en |
dc.subject | clinical feature | en |
dc.subject | community acquired pneumonia | en |
dc.subject | comparative study | en |
dc.subject | controlled study | en |
dc.subject | disease course | en |
dc.subject | disease severity | en |
dc.subject | female | en |
dc.subject | gene frequency | en |
dc.subject | genetic association | en |
dc.subject | genotype | en |
dc.subject | heterozygote | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | multicenter study | en |
dc.subject | polymerase chain reaction | en |
dc.subject | priority journal | en |
dc.subject | promoter region | en |
dc.subject | protein blood level | en |
dc.subject | restriction fragment length polymorphism | en |
dc.subject | septic shock | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | adolescent | en |
dc.subject | bacterial infection | en |
dc.subject | clinical trial | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | genotype | en |
dc.subject | middle aged | en |
dc.subject | pathology | en |
dc.subject | very elderly | en |
dc.subject | young adult | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Bacterial Infections | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Interleukin-8 | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Young Adult | en |
dc.subject | Springer Verlag | en |
dc.title | Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections | en |
dc.type | journalArticle | en |