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dc.creatorGeorgianos P.I., Vaios V., Eleftheriadis T., Zebekakis P.E., Liakopoulos V.en
dc.date.accessioned2023-01-31T07:40:48Z
dc.date.available2023-01-31T07:40:48Z
dc.date.issued2021
dc.identifier10.2174/1570161118666200403142451
dc.identifier.issn15701611
dc.identifier.urihttp://hdl.handle.net/11615/72151
dc.description.abstractBackground: Among patients with end-stage kidney disease (ESKD), arterial stiffness is considered as a powerful predictor of cardiovascular (CV) morbidity and mortality. However, the relevance of aortic pulse wave velocity (PWV) as a prognostic biomarker for CV risk estimation is not yet fully clear. Methods: We performed a systematic search of Medline/PubMed database from inception through August 21, 2019 to identify observational cohort studies conducted in ESKD patients and exploring the association of PWV with CV events and mortality. Results: Whereas “historical” cohort studies showed aortic PWV to be associated with higher risk of CV and all-cause mortality, recent studies failed to reproduce the independent predictive value of aortic PWV in older ESKD patients. Studies using state-of-the-art prognostic tests showed that the addition of aortic PWV to standard clinical risk scores could only modestly improve CV risk reclassification. Studies associating improvement in PWV in response to blood pressure (BP)-lowering with improvement in survival cannot demonstrate direct cause-and-effect associations due to their observational design and absence of accurate methodology to assess the BP burden. Conclusion: Despite the strong pathophysiological relevance of arterial stiffness as a mediator of CV disease in ESKD, the assessment of aortic PWV for CV risk stratification in this population appears to be of limited value. Whether aortic PWV assessment is valuable in guiding CV risk factor management and whether such a therapeutic approach is translated into improvement in clinical outcomes, is an issue of clinical relevance that warrants investigation in properly-designed randomized trials. © 2021 Bentham Science Publishers.en
dc.language.isoenen
dc.sourceCurrent Vascular Pharmacologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85096926276&doi=10.2174%2f1570161118666200403142451&partnerID=40&md5=b242986fa2a4596d9ade3ba660fc8b43
dc.subjectbiological markeren
dc.subjectall cause mortalityen
dc.subjectaortic bifurcationen
dc.subjectaortic pulse wave velocityen
dc.subjectarterial stiffnessen
dc.subjectblood pressureen
dc.subjectcardiovascular diseaseen
dc.subjectcardiovascular mortalityen
dc.subjectcardiovascular risken
dc.subjectchronic kidney failureen
dc.subjectdiagnostic accuracyen
dc.subjectdiastolic blood pressureen
dc.subjectend stage renal diseaseen
dc.subjectestimated glomerular filtration rateen
dc.subjecthazard ratioen
dc.subjectheart left ventricle hypertrophyen
dc.subjecthemodialysisen
dc.subjecthumanen
dc.subjectincidenceen
dc.subjectmean arterial pressureen
dc.subjectnephrectomyen
dc.subjectnuclear magnetic resonance imagingen
dc.subjectoutcome assessmenten
dc.subjectperipheral occlusive artery diseaseen
dc.subjectpredictive valueen
dc.subjectpulse pressureen
dc.subjectpulse waveen
dc.subjectReviewen
dc.subjectrisk assessmenten
dc.subjectrisk factoren
dc.subjectspeckle tracking echocardiographyen
dc.subjectsystolic blood pressureen
dc.subjecttreatment failureen
dc.subjectarterial stiffnessen
dc.subjectcardiovascular diseaseen
dc.subjectchronic kidney failureen
dc.subjectmortalityen
dc.subjectobservational studyen
dc.subjectpathophysiologyen
dc.subjectprognosisen
dc.subjectpulse waveen
dc.subjectrisk assessmenten
dc.subjectCardiovascular Diseasesen
dc.subjectHeart Disease Risk Factorsen
dc.subjectHumansen
dc.subjectKidney Failure, Chronicen
dc.subjectObservational Studies as Topicen
dc.subjectPredictive Value of Testsen
dc.subjectPrognosisen
dc.subjectPulse Wave Analysisen
dc.subjectRisk Assessmenten
dc.subjectVascular Stiffnessen
dc.subjectBentham Science Publishersen
dc.titlePulse wave velocity assessment for cardiovascular risk prognostication in eskd: Weighting recent evidenceen
dc.typeotheren


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