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Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

dc.creatorGeorgiadis M.-O., Kourbeli V., Ioannidou V., Karakitsios E., Papanastasiou I., Tsotinis A., Komiotis D., Vocat A., Cole S.T., Taylor M.C., Kelly J.M.en
dc.date.accessioned2023-01-31T07:40:40Z
dc.date.available2023-01-31T07:40:40Z
dc.date.issued2019
dc.identifier10.1016/j.bmcl.2019.04.010
dc.identifier.issn0960894X
dc.identifier.urihttp://hdl.handle.net/11615/72127
dc.description.abstractIn this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia–f and IIa–f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity. © 2019 Elsevier Ltden
dc.language.isoenen
dc.sourceBioorganic and Medicinal Chemistry Lettersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064075312&doi=10.1016%2fj.bmcl.2019.04.010&partnerID=40&md5=9f1236d5ebe5adbbcaea6624b76c94c1
dc.subjectaliphatic amineen
dc.subjectantitrypanosomal agenten
dc.subjectdiphenoxyadamantane alkylamineen
dc.subjecttuberculostatic agenten
dc.subjectunclassified drugen
dc.subjectadamantaneen
dc.subjectamineen
dc.subjectantitrypanosomal agenten
dc.subjecttuberculostatic agenten
dc.subjectantibacterial activityen
dc.subjectArticleen
dc.subjectbacterial growthen
dc.subjectcontrolled studyen
dc.subjectdrug structureen
dc.subjectdrug synthesisen
dc.subjectgrowth inhibitionen
dc.subjectMycobacterium tuberculosisen
dc.subjectnonhumanen
dc.subjecttrypanocidal activityen
dc.subjectTrypanosoma bruceien
dc.subjectchemical structureen
dc.subjectchemistryen
dc.subjectdose responseen
dc.subjectdrug effecten
dc.subjectdrug sensitivityen
dc.subjectstructure activity relationen
dc.subjectsynthesisen
dc.subjectTrypanosoma brucei bruceien
dc.subjectAdamantaneen
dc.subjectAminesen
dc.subjectAntitubercular Agentsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectMolecular Structureen
dc.subjectMycobacterium tuberculosisen
dc.subjectParasitic Sensitivity Testsen
dc.subjectStructure-Activity Relationshipen
dc.subjectTrypanocidal Agentsen
dc.subjectTrypanosoma brucei bruceien
dc.subjectElsevier Ltden
dc.titleSynthesis of diphenoxyadamantane alkylamines with pharmacological interesten
dc.typejournalArticleen


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