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A model of lung surfactant dynamics based on intrinsic interfacial compressibility

dc.creatorBouchoris K., Bontozoglou V.en
dc.date.accessioned2023-01-31T07:39:23Z
dc.date.available2023-01-31T07:39:23Z
dc.date.issued2021
dc.identifier10.1016/j.colsurfa.2021.126839
dc.identifier.issn09277757
dc.identifier.urihttp://hdl.handle.net/11615/71892
dc.description.abstractA minimum model for the description of lung surfactant dynamics during consecutive compression/relaxation cycles is proposed. The model is based on Frumkin/Langmuir equilibrium and on an equation of state that includes rigorously the intrinsic compressibility of the densely packed monolayer. Adsorption/desorption dynamics is taken to be kinetically-limited, and film collapse during extreme compression is accounted for by a sublayer reservoir and a simple kinetic expression for monolayer replenishment during re-expansion. The model is validated and found to agree quantitatively with independent data in the literature, taken at physiologically relevant conditions. The best-fit values of the key model parameters are discussed and found to be physically meaningful. Finally, the characteristics of dilatational elasticity, as predicted by the model, are considered. © 2021 Elsevier B.V.en
dc.language.isoenen
dc.sourceColloids and Surfaces A: Physicochemical and Engineering Aspectsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85106879071&doi=10.1016%2fj.colsurfa.2021.126839&partnerID=40&md5=91c76c1abde626657288940260633d00
dc.subjectBiological organsen
dc.subjectCompressibilityen
dc.subjectElasticityen
dc.subjectEquations of stateen
dc.subjectMonolayersen
dc.subjectPhospholipidsen
dc.subjectPhysiological modelsen
dc.subjectSurface active agentsen
dc.subject0000en
dc.subjectAdsorption ratesen
dc.subjectCompression-relaxation cyclingen
dc.subjectIntrinsic surface compressibilityen
dc.subjectLangmuirsen
dc.subjectLung surfactantsen
dc.subjectMinimum modelsen
dc.subjectPulmonary surfactantsen
dc.subjectSurface elasticitiesen
dc.subjectTemperature variablesen
dc.subjectSurface tensionen
dc.subjectadlayeren
dc.subjectlung surfactanten
dc.subjectadsorption kineticsen
dc.subjectArticleen
dc.subjectcompressionen
dc.subjectdesorptionen
dc.subjectelasticityen
dc.subjectmodelen
dc.subjectmolecular dynamicsen
dc.subjectpredictionen
dc.subjectquantitative analysisen
dc.subjectsurface tensionen
dc.subjectthermodynamicsen
dc.subjectElsevier B.V.en
dc.titleA model of lung surfactant dynamics based on intrinsic interfacial compressibilityen
dc.typejournalArticleen


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