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Genetic variability of the HPV16 early genes and LCR. Present and future perspectives

dc.creatorBletsa G., Zagouri F., Amoutzias G.D., Nikolaidis M., Zografos E., Markoulatos P., Tsakogiannis D.en
dc.date.accessioned2023-01-31T07:38:34Z
dc.date.available2023-01-31T07:38:34Z
dc.date.issued2021
dc.identifier10.1017/erm.2021.18
dc.identifier.issn14623994
dc.identifier.urihttp://hdl.handle.net/11615/71713
dc.description.abstractHuman papillomavirus 16 (HPV16) infection is the aetiologic factor for the development of cervical dysplasia and is regarded as highly carcinogen, because it is implicated in more than 50% of cervical cancer cases, worldwide. The tumourigenic potential of HPV16 has triggered the extensive sequence analysis of viral genome in order to identify nucleotide variations and amino acid substitutions that influence viral oncogenicity and subsequently the initiation and progression of cervical cancer. Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Ε7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised. In addition, numerous novel HPV16 mutations are observed among the studied populations from various geographic regions, hence advocating that different HPV16 strains seem to emerge with different tumourigenic capacities. The present review focuses on the variability of the early genes and the long control region, emphasising on the association of specific mutations with the development of severe dysplasia. Finally, it evaluates whether specific regions of HPV16 DNA are able to serve as valuable biomarkers for cervical cancer risk. Copyright © The Author(s), 2021. Published by Cambridge University Press.en
dc.language.isoenen
dc.sourceExpert Reviews in Molecular Medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85120804231&doi=10.1017%2ferm.2021.18&partnerID=40&md5=48a3cd7857955412ad46d12b5fd9f1da
dc.subjectprotein E6en
dc.subjectprotein E7en
dc.subjectvirus DNAen
dc.subjectoncoproteinen
dc.subjectrepressor proteinen
dc.subjectamino acid substitutionen
dc.subjectcancer risken
dc.subjectE1 geneen
dc.subjectE2 geneen
dc.subjectE4 geneen
dc.subjectE5 geneen
dc.subjectE6 oncogeneen
dc.subjectE7 oncogeneen
dc.subjectepistasisen
dc.subjectgene duplicationen
dc.subjectgene mutationen
dc.subjectgenetic heterogeneityen
dc.subjectgenetic variabilityen
dc.subjecthumanen
dc.subjectHuman papillomavirus type 16en
dc.subjectL1 geneen
dc.subjectlong control regionen
dc.subjectnonhumanen
dc.subjectoncogeneen
dc.subjectReviewen
dc.subjectsequence analysisen
dc.subjectsquamous intraepithelial lesion of the cervixen
dc.subjectuterine cervix canceren
dc.subjectuterine cervix dysplasiaen
dc.subjectvirus carcinogenesisen
dc.subjectvirus geneen
dc.subjectvirus genomeen
dc.subjectvirus replicationen
dc.subjectWarburg effecten
dc.subjectfemaleen
dc.subjectgeneticsen
dc.subjectHuman papillomavirus type 16en
dc.subjectpapillomavirus infectionen
dc.subjectuterine cervix tumoren
dc.subjectFemaleen
dc.subjectHuman papillomavirus 16en
dc.subjectHumansen
dc.subjectOncogene Proteins, Viralen
dc.subjectPapillomavirus Infectionsen
dc.subjectRepressor Proteinsen
dc.subjectUterine Cervical Neoplasmsen
dc.subjectCambridge University Pressen
dc.titleGenetic variability of the HPV16 early genes and LCR. Present and future perspectivesen
dc.typeotheren


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