Όλο το DSpace

Εμφάνιση απλής εγγραφής

Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers

dc.creatorBegas E., Tsioutsiouliti A., Kouvaras E., Haroutounian S.A., Kasiotis K.M., Kouretas D., Asprodini E.en
dc.date.accessioned2023-01-31T07:37:14Z
dc.date.available2023-01-31T07:37:14Z
dc.date.issued2017
dc.identifier10.1016/j.fct.2016.12.021
dc.identifier.issn02786915
dc.identifier.urihttp://hdl.handle.net/11615/71323
dc.description.abstractPeppermint leaves are widely used for the symptomatic treatment of digestive disorders. Previous studies have shown significant effects of its natural products on human enzyme activity; however, there is no study available concerning the effects of peppermint tea on metabolizing enzymes in humans. Aim of the present study was to investigate the effect of peppermint tea on CYP1A2, CYP2A6, Xanthine Oxidase (XO), N-acetyltranferase-2 (NAT2) and UDP-glucuronosyltransferases-1A1/1A6 (UGT1A1/1A6) activities in healthy subjects. Four males and five females consumed peppermint tea (2 g of dry leaves/200 mL water, twice daily) for six days. CYP1A2, CYP2A6, XO, NAT2 and UGT1A1/1A6 activities were determined before and at the end of the study period, using the following caffeine and paracetamol metabolic ratios: CYP1A2: 17MX/137MX (saliva) and (AFMU+1MU+1MX)/17MU (urine); CYP2A6: 17MU/(17MU + 17MX), XO: 1MU/(1MU+1MX), NAT2, AFMU/(AFMU+1MU+1MX) and UGT1A1/1A6 glucuronidated/total paracetamol, all determined in urine. NAT2 metabolic ratio was significantly reduced following peppermint consumption (0.15 ± 0.13 vs 0.14 ± 0.13; p < 0.05). CYP1A2 urine and saliva indices were reduced, yet not significantly, following peppermint consumption (urine: 3.17 ± 1.08 vs 2.91 ± 0.76, saliva: 0.56 ± 0.12 vs 0.50 ± 0.12; p > 0.05). Peppermint had no influence on CYP2A6, XO and UGT1A1/1A6 indices. Daily ingestion of peppermint tea may alter pharmacokinetics of clinically administered drugs and promote cancer chemoprevention through NAT2 inhibition. © 2016 Elsevier Ltden
dc.language.isoenen
dc.sourceFood and Chemical Toxicologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85008698377&doi=10.1016%2fj.fct.2016.12.021&partnerID=40&md5=8bf88b2df7feece933c16775301664ae
dc.subject1 methyluric aciden
dc.subject1 methylxanthineen
dc.subject1,7 dimethyluric aciden
dc.subject1,7 methylxanthineen
dc.subjectarylamine acetyltransferaseen
dc.subjectcaffeineen
dc.subjectcytochrome P450 1A2en
dc.subjectcytochrome P450 2A6en
dc.subjectglucuronosyltransferase 1A1en
dc.subjectglucuronosyltransferase 1A6en
dc.subjectparacetamolen
dc.subjectunclassified drugen
dc.subjectxanthine oxidaseen
dc.subjectarylamine acetyltransferaseen
dc.subjectCYP1A2 protein, humanen
dc.subjectCYP2A6 protein, humanen
dc.subjectcytochrome P450 1A2en
dc.subjectcytochrome P450 2A6en
dc.subjectglucuronosyltransferaseen
dc.subjectNAT2 protein, humanen
dc.subjectplant extracten
dc.subjectteaen
dc.subjectxanthine oxidaseen
dc.subjectadulten
dc.subjectArticleen
dc.subjectcancer preventionen
dc.subjectchemical compositionen
dc.subjectcontrolled studyen
dc.subjectdrug glucuronidationen
dc.subjectelectrospray mass spectrometryen
dc.subjectenzyme activityen
dc.subjectenzyme analysisen
dc.subjectenzyme inhibitionen
dc.subjectfemaleen
dc.subjectfluid intakeen
dc.subjectfood analysisen
dc.subjectfood drug interactionen
dc.subjectherbal teaen
dc.subjecthigh performance liquid chromatographyen
dc.subjecthumanen
dc.subjecthuman experimenten
dc.subjectin vivo studyen
dc.subjectmaleen
dc.subjectnormal humanen
dc.subjectopen studyen
dc.subjectsaliva levelen
dc.subjecturinalysisen
dc.subjecturine levelen
dc.subjectchemistryen
dc.subjectdrug effectsen
dc.subjectgene expression regulationen
dc.subjectliquid chromatographyen
dc.subjectmass spectrometryen
dc.subjectMentha piperitaen
dc.subjectmetabolismen
dc.subjectmiddle ageden
dc.subjectteaen
dc.subjectyoung adulten
dc.subjectAdulten
dc.subjectArylamine N-Acetyltransferaseen
dc.subjectChromatography, Liquiden
dc.subjectCytochrome P-450 CYP1A2en
dc.subjectCytochrome P-450 CYP2A6en
dc.subjectFemaleen
dc.subjectGene Expression Regulation, Enzymologicen
dc.subjectGlucuronosyltransferaseen
dc.subjectHealthy Volunteersen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMass Spectrometryen
dc.subjectMentha piperitaen
dc.subjectMiddle Ageden
dc.subjectPlant Extractsen
dc.subjectTeaen
dc.subjectXanthine Oxidaseen
dc.subjectYoung Adulten
dc.subjectElsevier Ltden
dc.titleEffects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteersen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής