The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

Agrawal R., MD FCRS, Betzler B., MBBS, Testi I., MD, Mahajan S., MBBS, Agarwal A., MS, Gunasekeran D.V., MD, Raje D., PhD, Aggarwal K., MS, Murthy S.I., DNB, Westcott M., FRCSOphth, Chee S.-P., FRCSEd, Mccluskey P., MD, Ho S.L., FRCSGlasg, Teoh S., FRCSEd, Cimino L., MD, Biswas J., MS, Narain S., MD, Agarwal M., MS, Mahendradas P., DNB, Khairallah M., MD, Jones N., FRCSOphth, Tugal-Tutkun I., MD, Babu K., DNB, Basu S., MS, Carreño E., MD, Lee R., PhD, Al-Dhibi H., MD, Bodaghi B., MD, Invernizzi A., MD, Goldstein D.A., MD, Herbort C.P., MD, Barisani-Asenbauer T., PhD, González-López J.J., PhD, Androudi S., MD, Bansal R., MS, Moharana B., MS, Esposti S., MD, Tasiopoulou A., MD, Nadarajah S., MD, Agarwal M., DNB, Abraham S., MD, Vala R., MD, Singh R., MS, Sharma A., MD, Sharma K., PhD, Zierhut M., PhD, Kon O.M., MRCP, Cunningham E.T., PhD, Kempen J.H., PhD, Nguyen Q.D., PhD, Pavesio C., FRCSOphth, Gupta V., MS

dc.creator	Agrawal R., MD FCRS, Betzler B., MBBS, Testi I., MD, Mahajan S., MBBS, Agarwal A., MS, Gunasekeran D.V., MD, Raje D., PhD, Aggarwal K., MS, Murthy S.I., DNB, Westcott M., FRCSOphth, Chee S.-P., FRCSEd, Mccluskey P., MD, Ho S.L., FRCSGlasg, Teoh S., FRCSEd, Cimino L., MD, Biswas J., MS, Narain S., MD, Agarwal M., MS, Mahendradas P., DNB, Khairallah M., MD, Jones N., FRCSOphth, Tugal-Tutkun I., MD, Babu K., DNB, Basu S., MS, Carreño E., MD, Lee R., PhD, Al-Dhibi H., MD, Bodaghi B., MD, Invernizzi A., MD, Goldstein D.A., MD, Herbort C.P., MD, Barisani-Asenbauer T., PhD, González-López J.J., PhD, Androudi S., MD, Bansal R., MS, Moharana B., MS, Esposti S., MD, Tasiopoulou A., MD, Nadarajah S., MD, Agarwal M., DNB, Abraham S., MD, Vala R., MD, Singh R., MS, Sharma A., MD, Sharma K., PhD, Zierhut M., PhD, Kon O.M., MRCP, Cunningham E.T., PhD, Kempen J.H., PhD, Nguyen Q.D., PhD, Pavesio C., FRCSOphth, Gupta V., MS	en
dc.date.accessioned	2023-01-31T07:30:32Z
dc.date.available	2023-01-31T07:30:32Z
dc.date.issued	2020
dc.identifier	10.1080/09273948.2020.1761400
dc.identifier.issn	09273948
dc.identifier.uri	http://hdl.handle.net/11615/70325
dc.description.abstract	Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU. © 2020, © 2020 Taylor & Francis Group, LLC.	en
dc.language.iso	en	en
dc.source	Ocular Immunology and Inflammation	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087505413&doi=10.1080%2f09273948.2020.1761400&partnerID=40&md5=ae1c4a436f8ff6df941f8754df37d588
dc.subject	steroid	en
dc.subject	tuberculostatic agent	en
dc.subject	Article	en
dc.subject	clinical feature	en
dc.subject	cohort analysis	en
dc.subject	female	en
dc.subject	follow up	en
dc.subject	human	en
dc.subject	iridocyclitis	en
dc.subject	major clinical study	en
dc.subject	male	en
dc.subject	multicenter study	en
dc.subject	ocular tuberculosis	en
dc.subject	recurrence free survival	en
dc.subject	retrospective study	en
dc.subject	steroid therapy	en
dc.subject	survival analysis	en
dc.subject	time to treatment	en
dc.subject	treatment failure	en
dc.subject	treatment outcome	en
dc.subject	tubercular anterior uveitis	en
dc.subject	visual acuity	en
dc.subject	visual impairment	en
dc.subject	Taylor and Francis Ltd	en
dc.title	The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis	en
dc.type	journalArticle	en

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