dc.creator | Aggelou K., Siapati E.K., Gerogianni I., Daniil Z., Gourgoulianis K., Ntanos I., Simantirakis E., Zintzaras E., Mollaki V., Vassilopoulos G. | en |
dc.date.accessioned | 2023-01-31T07:30:28Z | |
dc.date.available | 2023-01-31T07:30:28Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1155/2016/4961086 | |
dc.identifier.issn | 02780240 | |
dc.identifier.uri | http://hdl.handle.net/11615/70302 | |
dc.description.abstract | Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection.The Toll- Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk. © Copyright 2016 Kalliopi Aggelou et al. | en |
dc.language.iso | en | en |
dc.source | Disease Markers | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009455691&doi=10.1155%2f2016%2f4961086&partnerID=40&md5=5bab0fdcb2c3d79001d9a56adb1d8581 | |
dc.subject | myeloid differentiation factor 88 | en |
dc.subject | MYD88 protein, human | en |
dc.subject | myeloid differentiation factor 88 | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | Caucasian | en |
dc.subject | confidence interval | en |
dc.subject | controlled study | en |
dc.subject | disease predisposition | en |
dc.subject | female | en |
dc.subject | genetic analysis | en |
dc.subject | genetic risk | en |
dc.subject | genotype | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | inheritance | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | odds ratio | en |
dc.subject | pilot study | en |
dc.subject | risk factor | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | tuberculosis | en |
dc.subject | biological model | en |
dc.subject | case control study | en |
dc.subject | gene expression | en |
dc.subject | genetic association study | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | isolation and purification | en |
dc.subject | microbiology | en |
dc.subject | middle aged | en |
dc.subject | molecular typing | en |
dc.subject | Mycobacterium tuberculosis | en |
dc.subject | physiology | en |
dc.subject | promoter region | en |
dc.subject | Tuberculosis, Pulmonary | en |
dc.subject | Adult | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Gene Expression | en |
dc.subject | Genetic Association Studies | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Models, Genetic | en |
dc.subject | Molecular Typing | en |
dc.subject | Mycobacterium tuberculosis | en |
dc.subject | Myeloid Differentiation Factor 88 | en |
dc.subject | Odds Ratio | en |
dc.subject | Pilot Projects | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Promoter Regions, Genetic | en |
dc.subject | Risk Factors | en |
dc.subject | Tuberculosis, Pulmonary | en |
dc.subject | Hindawi Limited | en |
dc.title | The -938C>A polymorphism in MYD88 is associated with susceptibility to tuberculosis: A pilot study | en |
dc.type | journalArticle | en |