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dc.creatorZintzaras, E.en
dc.creatorStefanidis, I.en
dc.creatorSantos, M.en
dc.creatorVidal, F.en
dc.description.abstractCase-control studies that have investigated the association between alcoholism and alcohol-induced liver damage and the ADH2, ADH3, CYP2E1, and ADLH2 polymorphisms have reported controversial or inconclusive results. Thus, we conducted a meta-analysis of 50 association studies of the above polymorphisms. We explored potential sources of heterogeneity and bias, performed subgroup analyses by racial background and sex, performed sensitivity analyses for studies not in Hardy-Weinberg equilibrium, and performed a subgroup analysis for cases that met strict criteria for alcoholism. The present meta-analysis underscores significant associations of ADH2*1, ADH3*2, and ALDH2*1 alleles and the risk of alcoholism (OR = 1.89 [95% CI 1.56-2.28], 1.32 [95% CI 1.12-1.57], and 4.35 [95% CI 3.04-6.23], respectively). The subsequent subgroup analyses showed association for ADH2*1 and ADH3*2 only in East Asians (OR = 2.23 [95% CI 1.81-2.74] and 1.91 [95% CI 1.45-2.53], respectively) and East Asian males (OR = 2.21 [95% CI 1.57-3.10], 1.69 [95% CI 1.10-2.59], respectively). In East Asian males, the OR for ALDH2*1 was 3.66 (95% CI 1.68-7.96). In Caucasians, sensitivity analysis revealed an association for ADH2*1 in alcoholism (OR = 1.62 [95% CI 1.22-1.89]). When strict criteria were imposed, the pattern of results remained unaltered. For liver disease, there were no significant associations for ADH2*1, ADH3*2, or ALDH2*1 in all subpopulations. The CYP2E1 polymorphism showed no association whatsoever. There is evidence that alleles are mainly dominant. In conclusion, there was heterogeneity between studies in alcoholism for ADH2, ADH3, and ALDH2, and lack of bias in all polymorphisms. The above findings reinforce the need for more rigorous studies, and for regular synthesis of studies' results. Supplementary material for this article can be found on the HEPATOLOGY website ( jpages/0270-9139/suppmat/index.html). Copyright © 2006 by the American Association for the Study of Liver Diseases.en
dc.subjectalcohol dehydrogenaseen
dc.subjectaldehyde dehydrogenaseen
dc.subjectaldehyde dehydrogenase isoenzyme 2en
dc.subjectcytochrome P450 2E1en
dc.subjectadh2 geneen
dc.subjectadh3 geneen
dc.subjectadlh2 geneen
dc.subjectalcohol liver diseaseen
dc.subjectclinical trialen
dc.subjectdisease associationen
dc.subjectDNA polymorphismen
dc.subjectethnic differenceen
dc.subjectgenetic heterogeneityen
dc.subjectliver injuryen
dc.subjectmeta analysisen
dc.subjectpriority journalen
dc.subjectrisk assessmenten
dc.subjectsensitivity analysisen
dc.subjectstatistical analysisen
dc.subjectsystematic reviewen
dc.subjectAsian Continental Ancestry Groupen
dc.subjectCase-Control Studiesen
dc.subjectCytochrome P-450 CYP2E1en
dc.subjectEuropean Continental Ancestry Groupen
dc.subjectGene Frequencyen
dc.subjectLiver Diseases, Alcoholicen
dc.subjectPolymorphism, Geneticen
dc.titleDo alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?en

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