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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Association between AKT1 gene and Parkinson's disease: A protective haplotype

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Author
Xiromerisiou, G.; Hadjigeorgiou, G. M.; Papadimitriou, A.; Katsarogiannis, E.; Gourbali, V.; Singleton, A. B.
Date
2008
DOI
10.1016/j.neulet.2008.03.026
Keyword
AKT1
Parkinson's disease
association
haplotypes
LINKAGE DISEQUILIBRIUM
SIGNALING PATHWAY
SCHIZOPHRENIA
POLYMORPHISMS
POPULATIONS
APOPTOSIS
Neurosciences
Metadata display
Abstract
Variation in AKT1 has been associated with schizophrenia, bipolar disease and type 11 diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's disease (PD). We performed a case-control association analysis of AKT1 in a Greek cohort of PD using four tagging SNPs and five constructed haplotypes. To assess the structure of this locus in different populations we have performed linkage disequilibrium (LD) analysis using these variants [dunning]. In multilocus analysis, the frequency of a four-SNP1 /2/3/4 haplotype was significantly higher in controls in comparison with PD patients (chi(2) = 19.76, p = 0.00009, OR = 0.11 C.I. = 0.03-0.35). The association remained significant even after Bonferroni correction for the number of haplotypes (p = 0.0002). So, this certain haplotype was significantly associated with reduced risk of the disease. The data presented here suggest the involvement of AKT1 in protection of PD through many possible mechanisms involving different signaling pathways that could be potential therapeutic targets in the future. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/11615/34711
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19705]
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