Ovulation induction and successful pregnancy outcome in two patients with Prop1 gene mutations
dc.creator | Voutetakis, A. | en |
dc.creator | Sertedaki, A. | en |
dc.creator | Livadas, S. | en |
dc.creator | Maniati-Christidi, M. | en |
dc.creator | Mademtzis, I. | en |
dc.creator | Bossis, I. | en |
dc.creator | Dacou-Voutetakis, C. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:54:04Z | |
dc.date.available | 2015-11-23T10:54:04Z | |
dc.date.issued | 2004 | |
dc.identifier | 10.1016/j.fertnstert.2004.03.026 | |
dc.identifier.issn | 0015-0282 | |
dc.identifier.uri | http://hdl.handle.net/11615/34641 | |
dc.description.abstract | Objective: To describe ovulation induction and pregnancy outcome in a unique model of genetically determined combined pituitary hormone deficiency (CPHD), with respect to the necessity for GH substitution therapy. Design: Case report. Setting: Academic units. Patient(s): Two patients with childhood onset of CPHD (GH, PRL, TSH, LH, FSH) caused by a genetic defect (GA296del mutation) of the Prop1 gene. Main Outcome Measure(s): Ovulation, pregnancy outcome, and fetal growth. Result(s): Successful pregnancy outcome and delivery of normal, full-term newborns were achieved in both patients with the use of gonadotropins and L-T, Growth hormone supplementation was not necessary. No lactation was observed. Conclusion(s): Patients with Prop1 gene mutations constitute a unique model for studying the role of GH and PRL in ovulation, pregnancy, and fetal growth. Our data indicate that for women with CPHD, ovulation and pregnancy are possible with a classic regimen for hypogonadotropic hypogonadism, without the need for GH substitution therapy. (Fertil Steril((R)) 2004;82:454-7. (C) 2004 by American Society for Reproductive Medicine.). | en |
dc.source.uri | <Go to ISI>://WOS:000223263000033 | |
dc.subject | combined pituitary hormone deficiency | en |
dc.subject | growth hormone | en |
dc.subject | ovulation | en |
dc.subject | prolactin | en |
dc.subject | Prop1 | en |
dc.subject | IN-VITRO FERTILIZATION | en |
dc.subject | PITUITARY-HORMONE DEFICIENCY | en |
dc.subject | BIOSYNTHETIC | en |
dc.subject | GROWTH-HORMONE | en |
dc.subject | OVARIAN STIMULATION | en |
dc.subject | POOR RESPONDER | en |
dc.subject | WOMEN | en |
dc.subject | GONADOTROPIN | en |
dc.subject | PROLACTIN | en |
dc.subject | SUBSTITUTION | en |
dc.subject | COTREATMENT | en |
dc.subject | Obstetrics & Gynecology | en |
dc.subject | Reproductive Biology | en |
dc.title | Ovulation induction and successful pregnancy outcome in two patients with Prop1 gene mutations | en |
dc.type | journalArticle | en |
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