Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders
dc.creator | Vlata, Z. | en |
dc.creator | Tsatsakis, A. | en |
dc.creator | Tzagournissakis, M. | en |
dc.creator | Krambovitis, E. | en |
dc.date.accessioned | 2015-11-23T10:53:51Z | |
dc.date.available | 2015-11-23T10:53:51Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.2174/187153012802002893 | |
dc.identifier.issn | 18715303 | |
dc.identifier.uri | http://hdl.handle.net/11615/34558 | |
dc.description.abstract | Botulinum neurotoxins (BoNTs) are used in the treatment of many neurological disorders. The primary structure of BoNTs shows a high degree of homology with the tetanus neurotoxin, the toxoid of which is used as a vaccine. Because of the potential cross-reactivity between these toxins, we investigated the effects of Botulinum neurotoxin A (BoNT/A) and tetanus toxoid on peripheral blood mononuclear cells (PBMC) and the corresponding serum antibody levels, in twenty patients who had been treated with BoNT/A. We observed very low PBMC immunostimulation by BoNT/A at the tested dose (15 units/ml), as demonstrated by the low lymphocyte proliferation, and the absence of detectable antibodies cross-reacting with tetanus. However, exposure of PBMC from tetanus-sensitized patients to both neurotoxins showed that BoNT/A exerted a co stimulatory effect on tetanus-stimulated cells. Interestingly, in flow cytometry analysis, BoNT/A seemed to also alter the ratio of naïve (CD45RA): memory/effector (CD45RO) T lymphocyte subsets, in favour of CD45RO. These preliminary data give a new insight on the potential immune crossreactivity between the two antigens. In view of the wide use of both neurotoxins, these immunotoxic effects merit a more detailed investigation. © 2012 Bentham Science Publishers. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84864755209&partnerID=40&md5=d4ec94864559423b2f8eb6ea3bce330c | |
dc.subject | Antibody assay | en |
dc.subject | Botulinum neurotoxin (A) | en |
dc.subject | PBMC proliferation | en |
dc.subject | Tetanus neurotoxin | en |
dc.subject | botulinum toxin A | en |
dc.subject | CD45RA antigen | en |
dc.subject | CD45RO antigen | en |
dc.subject | cross reacting antibody | en |
dc.subject | tetanus toxoid | en |
dc.subject | antibody blood level | en |
dc.subject | article | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | cross reaction | en |
dc.subject | drug cross reactivity | en |
dc.subject | drug effect | en |
dc.subject | drug megadose | en |
dc.subject | drug response | en |
dc.subject | flow cytometry | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | immune response | en |
dc.subject | immunostimulation | en |
dc.subject | low drug dose | en |
dc.subject | lymphocyte proliferation | en |
dc.subject | memory T lymphocyte | en |
dc.subject | neurologic disease | en |
dc.subject | peripheral blood mononuclear cell | en |
dc.subject | tetanus | en |
dc.subject | Antibodies, Bacterial | en |
dc.subject | Antibodies, Neutralizing | en |
dc.subject | Antigens, Bacterial | en |
dc.subject | Antigens, CD45 | en |
dc.subject | Bacterial Vaccines | en |
dc.subject | Botulinum Toxins, Type A | en |
dc.subject | Cell Proliferation | en |
dc.subject | Cells, Cultured | en |
dc.subject | Cross Reactions | en |
dc.subject | Cross-Priming | en |
dc.subject | Dose-Response Relationship, Immunologic | en |
dc.subject | Humans | en |
dc.subject | Immunity, Active | en |
dc.subject | Leukocytes, Mononuclear | en |
dc.subject | Lymphocyte Activation | en |
dc.subject | Metalloendopeptidases | en |
dc.subject | Nervous System Diseases | en |
dc.subject | Neuromuscular Agents | en |
dc.subject | Neurotoxins | en |
dc.subject | Pilot Projects | en |
dc.subject | T-Lymphocytes | en |
dc.subject | Tetanus Toxin | en |
dc.title | Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders | en |
dc.type | journalArticle | en |
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