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The effect of allopurinol on protein carbonyls and swimming performance in rats

dc.creatorVeskoukis, A. S.en
dc.creatorNikolaidis, M. G.en
dc.creatorKyparos, A.en
dc.creatorKokkinos, D.en
dc.creatorVaramenti, E.en
dc.creatorKouretas, D.en
dc.date.accessioned2015-11-23T10:53:39Z
dc.date.available2015-11-23T10:53:39Z
dc.date.issued2008
dc.identifier.issn10116583
dc.identifier.urihttp://hdl.handle.net/11615/34477
dc.description.abstractAllopurinol is an inhibitor of xanthine oxidase. Xanthine oxidase is a major contributor of free radicals during exercise. Previous studies have shown that free radicals are vital for physiological adaptations in exercise. The purpose of this study was to examine the effects of allopurinol, exercise and their combination on protein carbonyls (PC), as a marker of protein oxidative, after exhaustive swimming, denoting aerobic performance, in rats. Blood and gastrocnemius muscle samples were collected before and immediately after exercise and the respective time points after allopurinol administration. Protein carbonyls were determined in plasma, erythrocytes and muscle. Compared to their non-allopurinol treated counterparts, rats treated with allopurinol showed a 38.1% decrease in swimming performance, as indicated by the shorter swimming time to exhaustion. Exercise alone increased PC concentration in plasma, erythrocytes and gastrocnemius muscle. Similarly, allopurinol alone increased PC concentration in erythrocytes and gastrocnemius muscle. Our data illustrate that exercise and allopurinol alone induced protein oxidation. Xanthine oxidase inhibition provoked a significant reduction in physical performance. These findings may challenge the antioxidant effects of allopurinol. ©PHARMAKON-Press.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-45149089666&partnerID=40&md5=be39d0d10828163e971d9119adf994ca
dc.subjectEnduranceen
dc.subjectExhaustive exerciseen
dc.subjectFree radicalsen
dc.subjectProtein oxidationen
dc.subjectSkeletal muscleen
dc.subjectallopurinolen
dc.subjectcarbonyl derivativeen
dc.subjectprotein carbonyl derivativeen
dc.subjectxanthine oxidaseen
dc.subjectaerobic exerciseen
dc.subjectanimal experimenten
dc.subjectanimal tissueen
dc.subjectblood samplingen
dc.subjectconference paperen
dc.subjectcontrolled studyen
dc.subjectdrug effecten
dc.subjecterythrocyteen
dc.subjectgastrocnemius muscleen
dc.subjectmaleen
dc.subjectnonhumanen
dc.subjectoxidationen
dc.subjectprotein blood levelen
dc.subjectprotein carbonylationen
dc.subjectraten
dc.subjectsingle drug doseen
dc.subjectswimmingen
dc.titleThe effect of allopurinol on protein carbonyls and swimming performance in ratsen
dc.typejournalArticleen


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