Show simple item record

dc.creatorVavougios, G.en
dc.creatorPastaka, C.en
dc.creatorTsilioni, I.en
dc.creatorNatsios, G.en
dc.creatorSeitanidis, G.en
dc.creatorFlorou, E.en
dc.creatorGourgoulianis, K. I.en
dc.description.abstractOxidative stress has a central role in the pathophysiology of obstructive sleep apnea syndrome (OSAS). The DJ-1 protein functions as a sensor of oxidative stress, acting both as a reactive oxygen species scavenger (ROS) and an antioxidative response regulator. The aim of our study is to determine the serum levels of DJ-1 in OSAS patients and assess possible correlations with their clinical, demographical, and biochemical characteristics. The study included 120 subjects from the Sleep Disorder Laboratory of the University Hospital of Thessaly (100 males vs 20 females, mean age 48 +/- 10, Apnea-Hypopnea Index (AHI) > 5 episodes per hour of sleep). Subjects underwent full-night polysomnography (PSG) followed by morning blood sampling. Serum DJ-1 levels were determined via ELISA kits. Statistical analysis was performed using SPSS 19. The median DJ-1 levels were 56.7 ng/mL (IQR, 34.9-99.3 ng/mL). Statistically significant correlations were detected between DJ-1's levels and AHI (Spearman's rho = 0.189, P = 0.04), Desaturation Index (DI; Spearman's rho = 0.239, P = 0.012), and serum low-density lipoprotein (LDL) (Spearman's rho = -0.205, P = 0.042). DJ-1 may be a useful biomarker in OSAS due to its correlations with AHI and DI. The correlation with serum LDL warrants further investigation regarding possible implications in OSAS patients' cardiovascular comorbidities.en
dc.sourceSleep and Breathingen
dc.source.uri<Go to ISI>://WOS:000344784800031
dc.subjectObstructive sleep apneaen
dc.subjectSerum biomarkersen
dc.subjectOxidative stressen
dc.subjectClinical Neurologyen
dc.subjectRespiratory Systemen
dc.titleThe DJ-1 protein as a candidate biomarker in obstructive sleep apnea syndromeen

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record