dc.creator | Vamvakopoulos, N. V. | en |
dc.date.accessioned | 2015-11-23T10:53:10Z | |
dc.date.available | 2015-11-23T10:53:10Z | |
dc.date.issued | 1995 | |
dc.identifier | 10.1155/s0962935195000275 | |
dc.identifier.issn | 0962-9351 | |
dc.identifier.uri | http://hdl.handle.net/11615/34275 | |
dc.description.abstract | THIS review highlights key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticoids, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/inflammatory reaction by steroid hormones, from the perspective of the CRH system. | en |
dc.source.uri | <Go to ISI>://WOS:A1995RG39500001 | |
dc.subject | AUTOIMMUNITY | en |
dc.subject | CORTICOTROPIN RELEASING HORMONE | en |
dc.subject | ESTROGENS | en |
dc.subject | GLUCOCORTICOIDS | en |
dc.subject | GLUCOCORTICOID RECEPTOR | en |
dc.subject | GONADAL STEROIDS | en |
dc.subject | HEAT SHOCK | en |
dc.subject | PROTEINS | en |
dc.subject | HORMONAL REGULATION OF GENE EXPRESSION | en |
dc.subject | HYPOTHALAMIC-PITUITARY-ADRENAL AXIS | en |
dc.subject | IMMUNE INFLAMMATORY REACTION | en |
dc.subject | SEXUAL DIMORPHISM | en |
dc.subject | STRESS RESPONSE | en |
dc.subject | PITUITARY-ADRENAL AXIS | en |
dc.subject | CENTRAL NERVOUS-SYSTEM | en |
dc.subject | 3',5'-CYCLIC | en |
dc.subject | ADENOSINE-MONOPHOSPHATE | en |
dc.subject | GLUCOCORTICOID RECEPTOR-BINDING | en |
dc.subject | WALL INDUCED | en |
dc.subject | POLYARTHRITIS | en |
dc.subject | BLOOD MONONUCLEAR-CELLS | en |
dc.subject | FACTOR GENE-EXPRESSION | en |
dc.subject | MESSENGER-RNA LEVELS | en |
dc.subject | RAT LEYDIG-CELLS | en |
dc.subject | ACTH RELEASE | en |
dc.subject | Cell Biology | en |
dc.subject | Immunology | en |
dc.title | SEXUAL DIMORPHISM OF STRESS-RESPONSE AND IMMUNE INFLAMMATORY REACTION - THE CORTICOTROPIN-RELEASING HORMONE PERSPECTIVE | en |
dc.type | journalArticle | en |