SEXUAL DIMORPHISM OF STRESS-RESPONSE AND IMMUNE INFLAMMATORY REACTION - THE CORTICOTROPIN-RELEASING HORMONE PERSPECTIVE

Abstract

THIS review highlights key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticoids, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/inflammatory reaction by steroid hormones, from the perspective of the CRH system.