Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population
dc.creator | Tsezou, A. | en |
dc.creator | Tzetis, M. | en |
dc.creator | Giannatou, E. | en |
dc.creator | Spanos, I. | en |
dc.creator | Roma, E. | en |
dc.creator | Fretzayas, A. | en |
dc.creator | Kanavakis, E. | en |
dc.creator | Kitsiou-Tzeli, S. | en |
dc.date.accessioned | 2015-11-23T10:51:12Z | |
dc.date.available | 2015-11-23T10:51:12Z | |
dc.date.issued | 2009 | |
dc.identifier | 10.1089/gtmb.2008.0095 | |
dc.identifier.issn | 1945-0265 | |
dc.identifier.uri | http://hdl.handle.net/11615/33859 | |
dc.description.abstract | We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, by conducting a case-control study that included 198 adult patients with cholelithiasis and 152 healthy controls both of Greek origin. Three genotypes were found: 7/7 (17.8% in controls and 23.3% in patients), 6/7 (33.5% in controls and 46.5% in patients), and normal homozygous 6/6 (48.7% in controls and 30.3% in patients). The Gilbert UGT1A1 genotypes 6/7 and 7/7 show significant association (odds ratio 2.225, 95% confidence interval 1.373-3.605, p = 0.001, and odds ratio 2.101, 95% confidence interval 1.171-3.770, p = 0.013, respectively) with cholelithiasis risk. This association supports the theory that genetic factors are responsible for a fraction of symptomatic gallstone disease; however, further studies are required in different ethnic groups to fully elucidate the involvement of Gilbert syndrome in gallstone disease. | en |
dc.source | Genetic Testing and Molecular Biomarkers | en |
dc.source.uri | <Go to ISI>://WOS:000265065900023 | |
dc.subject | HEREDITARY SPHEROCYTOSIS | en |
dc.subject | GALLSTONE FORMATION | en |
dc.subject | SERUM BILIRUBIN | en |
dc.subject | UGT1A1 | en |
dc.subject | PROMOTER | en |
dc.subject | POLYMORPHISM | en |
dc.subject | DISEASE | en |
dc.subject | HYPERBILIRUBINEMIA | en |
dc.subject | COINHERITANCE | en |
dc.subject | PATHOGENESIS | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.subject | Genetics & Heredity | en |
dc.title | Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |