dc.creator | Tsantes, A. E. | en |
dc.creator | Kopterides, P. | en |
dc.creator | Bonovas, S. | en |
dc.creator | Bagos, P. | en |
dc.creator | Antonakos, G. | en |
dc.creator | Nikolopoulos, G. K. | en |
dc.creator | Gialeraki, A. | en |
dc.creator | Kapsimali, V. | en |
dc.creator | Kyriakou, E. | en |
dc.creator | Kokori, S. | en |
dc.creator | Dima, K. | en |
dc.creator | Armaganidis, A. | en |
dc.creator | Tsangaris, I. | en |
dc.date.accessioned | 2015-11-23T10:50:52Z | |
dc.date.available | 2015-11-23T10:50:52Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0375-9393 | |
dc.identifier.uri | http://hdl.handle.net/11615/33801 | |
dc.description.abstract | Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains controversial. Our aim was to assess simultaneously the effect of the ACE I/D polymorphisms as well as the serum and BALF ACE levels on prognosis of patients with ARDS. Methods. Sixty-nine mechanically ventilated patients with ALI/ARDS were recruited. ACE activity levels both in serum and BALF were assessed by chemical methods. Patients were genotyped for ACE I/D polymorphisms. Time-to-event analysis evaluated the variables associated with the 28-day and 90-day mortality. Finally, we performed a meta-analysis of studies examining the association between ACE I/D polymorphisms and mortality of ALI/ARDS patients. Results. In the multivariable model, age, lung compliance, serum lactate and serum ACE levels were significantly associated with both 28-day and 90-day mortality. No significant correlation was found between serum and BALF ACE levels (Spearman's rho=0.054; P=0.66). Serum ACE concentrations were significantly higher (P=0.046) in patients with D/D genotype versus the two other groups combined (I/D and I/I genotypes). The meta-analysis of 6 studies (including ours) provided evidence that D allele is significantly associated with increased mortality in ALI/ARDS patients, yielding a per-allele odds ratio of 1.76 (95% CI: 1.19, 2.59). Conclusion. Serum ACE levels appear to be affected by the I/D polymorphism and are correlated with prognosis in patients with ALI/ARDS indicating that further investigation of the clinical significance of the ACE in ARDS might be of value. | en |
dc.source.uri | <Go to ISI>://WOS:000326410400008 | |
dc.subject | Angiotensin-converting enzyme inhibitors | en |
dc.subject | Polymorphism, genetic | en |
dc.subject | Respiratory distress syndrome, adult | en |
dc.subject | ACUTE LUNG INJURY | en |
dc.subject | INSERTION DELETION POLYMORPHISM | en |
dc.subject | ARDS | en |
dc.subject | METAANALYSIS | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | MORTALITY | en |
dc.subject | SEPSIS | en |
dc.subject | BIAS | en |
dc.subject | Anesthesiology | en |
dc.subject | Critical Care Medicine | en |
dc.title | Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome | en |
dc.type | journalArticle | en |