Mostrar el registro sencillo del ítem
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
dc.creator | Triantafyllou, A. | en |
dc.creator | Liakos, P. | en |
dc.creator | Tsakalof, A. | en |
dc.creator | Chachami, G. | en |
dc.creator | Paraskeva, E. | en |
dc.creator | Molyvdas, P. A. | en |
dc.creator | Georgatsou, E. | en |
dc.creator | Simos, G. | en |
dc.creator | Bonanou, S. | en |
dc.date.accessioned | 2015-11-23T10:50:19Z | |
dc.date.available | 2015-11-23T10:50:19Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1080/10715760601055324 | |
dc.identifier.issn | 1071-5762 | |
dc.identifier.uri | http://hdl.handle.net/11615/33711 | |
dc.description.abstract | Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not been determined. In this study we characterized the induction of HIF-1 alpha and the inhibition of cell proliferation caused by quercetin in HeLa and ASM ( airway smooth muscle) cells and examined the effect of iron on these processes. Furthermore, we investigated the relevance of the intracellular levels of quercetin to HIF-1 alpha expression and cell proliferation. Our data demonstrate that quercetin depletes intracellular calcein - chelatable iron and that supplying additional iron from extracellular or intracellular pools abrogates the induction of HIF-1 alpha by quercetin. Moreover, addition of iron reverses the quercetin- induced inhibition of DNA synthesis, cell proliferation and cycle progression, but to different extents, depending on cell type. We propose that quercetin stabilises HIF-1 alpha and inhibits cell proliferation predominantly by decreasing the concentration of intracellular iron through chelation. | en |
dc.source | Free Radical Research | en |
dc.source.uri | <Go to ISI>://WOS:000245588800013 | |
dc.subject | hypoxia-inducible factor-1 | en |
dc.subject | HIF-1 alpha | en |
dc.subject | quercetin | en |
dc.subject | iron | en |
dc.subject | ascorbate | en |
dc.subject | ferric citrate | en |
dc.subject | HYPOXIA-INDUCIBLE FACTOR | en |
dc.subject | SMOOTH-MUSCLE-CELLS | en |
dc.subject | SIGNAL-TRANSDUCTION | en |
dc.subject | ANTIOXIDANT ACTIVITY | en |
dc.subject | DIETARY FLAVONOIDS | en |
dc.subject | GENE-EXPRESSION | en |
dc.subject | TRANSCRIPTIONAL ACTIVITY | en |
dc.subject | FACTOR 1-ALPHA | en |
dc.subject | HEART-DISEASE | en |
dc.subject | CANCER-CELLS | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron | en |
dc.type | journalArticle | en |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |