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dc.creatorStefanidis, I.en
dc.creatorZarogiannis, S.en
dc.creatorHatzoglou, C.en
dc.creatorLiakopoulos, V.en
dc.creatorKourti, P.en
dc.creatorPoultsidi, A.en
dc.creatorMertens, P. R.en
dc.creatorGourgoulianis, K.en
dc.creatorMolyvdas, P. A.en
dc.date.accessioned2015-11-23T10:48:49Z
dc.date.available2015-11-23T10:48:49Z
dc.date.issued2005
dc.identifier10.1111/j.1525-1594.2005.00157.x
dc.identifier.issn0160564X
dc.identifier.urihttp://hdl.handle.net/11615/33427
dc.description.abstractThe peritoneal mesothelium constitutes an ion transport barrier that is taken advantage of in peritoneal dialysis. The aim of this study was to investigate the effects of epinephrine on the electrical transmesothelial resistance (RTM) of the isolated parietal sheep peritoneum by means of Ussing-type chamber experiments. Intact parietal (diaphragmatic) peritoneal samples were obtained from adult sheep immediately after sacrifice and transferred within 0.5 h to the laboratory in a cooled Krebs-Ringer bicarbonate solution (4°C, pH 7.5), bubbled with 95% O2-5% CO2. A parietal peritoneal planar sheet was mounted in a Ussing-type chamber. Epinephrine (10-7 M) was added to the apical and the basolateral side. The RTM was measured before and serially after the addition of epinephrine for 30 min. As active ion transport is temperature-dependent, all measurements were performed at 37°C. The results were calculated as means with standard errors (x ± SE) of six independent experiments. The control RTM was 20.05 ± 0.61 Ω·cm2. The addition of epinephrine to the basolateral side within 1 min induced an increase of R TM to 21.8 ± 0.45 Ω·cm2, which decreased thereafter progressively to reach control values again after 15 min. A similar effect of epinephrine on the apical side was apparent with a rapid rise of RTM to 22.5 ± 0.66 Ω·cm2 and a subsequent decrease (P < 0.05). A clear association between the RTM and active ion transport was established from previous studies. The results of our study indicate a rapid action of epinephrine on the parietal peritoneum permeability.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-33644787780&partnerID=40&md5=df7f7dc0171929dc45724a48f2b533bf
dc.subjectEpinephrineen
dc.subjectPeritoneumen
dc.subjectPermeabilityen
dc.subjectTransmesothelial resistanceen
dc.subjectUssing-type chamberen
dc.subjectadrenalinen
dc.subjectbicarbonateen
dc.subjectRinger solutionen
dc.subjectanimal tissueen
dc.subjectapical membraneen
dc.subjectarticleen
dc.subjectbasolateral membraneen
dc.subjectcontrolled studyen
dc.subjectelectric resistanceen
dc.subjectfemaleen
dc.subjectin vitro studyen
dc.subjection transporten
dc.subjectmaleen
dc.subjectmembrane permeabilityen
dc.subjectmesotheliumen
dc.subjectnonhumanen
dc.subjectperitoneal dialysisen
dc.subjectpriority journalen
dc.subjectsheepen
dc.subjecttemperature dependenceen
dc.subjectanimalen
dc.subjectbioreactoren
dc.subjectdrug effecten
dc.subjectelectrochemistryen
dc.subjectimpedanceen
dc.subjectinstrumentationen
dc.subjectmethodologyen
dc.subjectphysiologyen
dc.subjectOvis ariesen
dc.subjectAnimalsen
dc.subjectBioreactorsen
dc.subjectElectric Impedanceen
dc.titleEnhancement of the transmesothelial resistance of the parietal sheep peritoneum by epinephrine in vitro: Ussing-type chamber experimentsen
dc.typejournalArticleen


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