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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes

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Author
Stagos, D.; Spanou, C.; Margariti, M.; Stathopoulos, C.; Mamuris, Z.; Kazantzoglou, G.; Magiatis, P.; Kouretas, D.
Date
2007
DOI
10.1021/jf0635255
Keyword
grape extracts
Vitis vinifera
plant polyphenols
mitomycin C
human
lymphocytes
sister chromatid exchanges
CULTURED HUMAN-LYMPHOCYTES
TANNIC-ACID
HYDROGEN-PEROXIDE
GREEK
VARIETIES
PHENOLIC-ACIDS
FREE-RADICALS
SEED EXTRACT
SKIN EXTRACT
DNA-DAMAGE
ANTIOXIDANT
Agriculture, Multidisciplinary
Chemistry, Applied
Food Science &
Technology
Metadata display
Abstract
In the present study, the effects of extracts and polyphenol-rich fractions as well as monomer polyphenols identified in them, from both red and white grapes, on mitomycin C (MMC) induced sister chromatid exchanges (SCEs) in human peripheral blood lymphocytes were investigated. The grape extracts and two of the three polyphenol-rich fractions promoted MMC-induced SCEs at concentrations from 75 to 300 mu g/mL. However, none of the extracts or fractions alone induced SCEs. Thus, these results suggest caution especially with regard to the use of grape extracts as dietary supplements. On the other hand, the fact that these extracts were not genotoxic alone may indicate a selective activity against genetically damaged cells. This is the first study regarding the clastogenic effects of grape extracts in human cells. Moreover, from the tested polyphenols, caffeic acid, gallic acid, and rutin hydrate enhanced MMC-induced clastogenicity, whereas ferulic acid, protocatechuic acid, (+)-catechin, (-)-epicatechin, and trans-resveratrol had no effect at concentrations between 5 and 100 mu M. The differences in the chemical structures of the tested polyphenols may account for their differential effects on MMC clastogenicity.
URI
http://hdl.handle.net/11615/33333
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9728]
Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
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Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
Ψηφιακή Ελλάδα
ΕΣΠΑ 2007-2013