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Effect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-aspartate and [3H]-GABA from rat retina and hippocampus

dc.creatorSourlas, V.en
dc.creatorAthanasiou, V.en
dc.creatorVasilaki, A.en
dc.date.accessioned2015-11-23T10:47:59Z
dc.date.available2015-11-23T10:47:59Z
dc.date.issued2008
dc.identifier.issn10116583
dc.identifier.urihttp://hdl.handle.net/11615/33211
dc.description.abstractThe modulation of the enhanced release of [3H]-D-Aspartate and [3H]GABA following ischemia-like conditions was studied in rat retinal and hippocampal preparations using a superfusion system. Ischemia was simulated by a glucose-free medium equilibrated with 95%N2/5%CO 2. In this model the potential neuroprotective effect somatostatin on [3H]-D-Aspartate and [3H]GABA release induced by ischemia-like conditions were investigated. Retina was more resistant to ischemia compared to hippocampus. Somatostatin (SRIF-14) decreased ischemia-induced [3H]GABA release in both retina and hippocampus while the the sst2/5 somatostatin receptor selective agonist Octreotide decreased and the sst2 somatostatin receptor selective antagonist D-Tyr8 CYN 154806 increased the ischemia-induced [ 3H]-D-Aspartate from both retinal and hippocampal preparations indicating that endogenous somatostatin plays a neuroprotective role in both tissues through sst2 receptor activation, at least as far as the ischemia-induced [3H]-D-Aspartate release is concerned. ©PHARMAKON-Press.en
dc.sourceReview of Clinical Pharmacology and Pharmacokinetics, International Editionen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-45149108871&partnerID=40&md5=8222394a346a6e2e12af3e7c428e49fc
dc.subjectHippocampusen
dc.subjectIn vitro ischemiaen
dc.subjectRetinaen
dc.subjectSomatostatinen
dc.subjectSuperfusionen
dc.subject4 aminobutyric aciden
dc.subjectagents interacting with transmitter, hormone or drug receptorsen
dc.subjectch 275en
dc.subjectcyn 154806en
dc.subjectdextro aspartic aciden
dc.subjectoctreotideen
dc.subjectreceptor blocking agenten
dc.subjectsomatostatin 14en
dc.subjectsomatostatin receptoren
dc.subjectsomatostatin[8 dextro tryptophan]en
dc.subjectsrif 14en
dc.subject4 aminobutyric acid releaseen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectanimal tissueen
dc.subjectconference paperen
dc.subjectcontrolled studyen
dc.subjectdrug effecten
dc.subjectin vitro studyen
dc.subjectischemiaen
dc.subjectneuroprotectionen
dc.subjectneurosecretionen
dc.subjectnonhumanen
dc.subjectraten
dc.titleEffect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-aspartate and [3H]-GABA from rat retina and hippocampusen
dc.typejournalArticleen


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