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Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia

dc.creatorSmilevska, T.en
dc.creatorStamatopoulos, K.en
dc.creatorSamara, M.en
dc.creatorBelessi, C.en
dc.creatorTsompanakou, A.en
dc.creatorPaterakis, G.en
dc.creatorStavroyianni, N.en
dc.creatorAthanasiadou, I.en
dc.creatorChiotoglou, I.en
dc.creatorHadzidimitriou, A.en
dc.creatorAthanasiadou, A.en
dc.creatorDouka, V.en
dc.creatorSaloum, R.en
dc.creatorLaoutaris, N.en
dc.creatorAnagnostopoulos, A.en
dc.creatorFassas, A.en
dc.creatorStathakis, N.en
dc.creatorKollia, P.en
dc.date.accessioned2015-11-23T10:47:32Z
dc.date.available2015-11-23T10:47:32Z
dc.date.issued2006
dc.identifier10.1016/j.leukres.2005.06.006
dc.identifier.issn1452126
dc.identifier.urihttp://hdl.handle.net/11615/33100
dc.description.abstractTransferrin receptor (TfR)-1 and 2 mRNA and CD71 (TfR1) expression was analyzed in 118 CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level; 60% of CD71 (+) cases were IGH-mutated. All samples were TfR1 mRNA (+); TfR2-alpha/beta mRNA was detected in, respectively, 52/102 and 100/109 cases. Competitive RT-PCR showed widely divergent levels of TfR1 mRNA in cases with high CD71 expression, alluding to postrtanscriptional control of TfR1 expression in CLL. The almost uniformly high CD71 expression in CLL is in keeping with the activated status of neoplastic cells, regardless of IGH mutational load. © 2005 Elsevier Ltd. All rights reserved.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-28844495516&partnerID=40&md5=def3f6714e4660463557263d35da6090
dc.subjectB cellsen
dc.subjectChronic lymphocytic leukemiaen
dc.subjectIG genesen
dc.subjectIronen
dc.subjectTransferrin receptoren
dc.subjectCD71 antigenen
dc.subjectmessenger RNAen
dc.subjectreceptor subuniten
dc.subjecttransferrin receptor 2alphaen
dc.subjecttransferrin receptor 2betaen
dc.subjectunclassified drugen
dc.subjectadulten
dc.subjectageden
dc.subjectarticleen
dc.subjectchronic lymphatic leukemiaen
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectgene expressionen
dc.subjectgene sequenceen
dc.subjecthumanen
dc.subjecthuman tissueen
dc.subjectmaleen
dc.subjectmutagenesisen
dc.subjectpriority journalen
dc.subjectprotein determinationen
dc.subjectprotein expressionen
dc.subjectprotein functionen
dc.subjectreceptor densityen
dc.subjectreceptor intrinsic activityen
dc.subjectreverse transcription polymerase chain reactionen
dc.subjecttranscription regulationen
dc.subjecttumor cellen
dc.subjectAntigens, CDen
dc.subjectAntigens, CD38en
dc.subjectAntigens, Differentiation, T-Lymphocyteen
dc.subjectHumansen
dc.subjectImmunoglobulin Heavy Chainsen
dc.subjectImmunophenotypingen
dc.subjectLeukemia, Lymphocytic, Chronicen
dc.subjectMiddle Ageden
dc.subjectMutationen
dc.subjectReceptors, Transferrinen
dc.subjectRNA, Messengeren
dc.titleTransferrin receptor-1 and 2 expression in chronic lymphocytic leukemiaen
dc.typejournalArticleen


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