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Efficacy of marbofloxacin against respiratory infections of lambs
dc.creator | Skoufos, J. | en |
dc.creator | Christodoulopoulos, G. | en |
dc.creator | Fragkou, I. A. | en |
dc.creator | Tzora, A. | en |
dc.creator | Gougoulis, D. A. | en |
dc.creator | Orfanou, D. C. | en |
dc.creator | Tsiolaki, K. | en |
dc.creator | Fthenakis, G. C. | en |
dc.date.accessioned | 2015-11-23T10:47:29Z | |
dc.date.available | 2015-11-23T10:47:29Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1016/j.smallrumres.2006.07.012 | |
dc.identifier.issn | 0921-4488 | |
dc.identifier.uri | http://hdl.handle.net/11615/33086 | |
dc.description.abstract | The trial was carried out in a sheep flock with mixed Mannheimia haemolytica/Mycoplasma spp. respiratory infection; 60 lambs were included therein and allocated as follows: lambs in group MH were subcutaneously injected with marbofloxacin (3.0 mg/kg bodyweight) on two occasions, once daily 2 days apart - lambs in group ML3 were given marbofloxacin (2.0 mg/kg) on three occasion, once daily for three consecutive days - lambs in group ML2 were given marbofloxacin (2.0 mg/kg) on two occasions, 2 days apart - lambs in group T were subcutaneously injected with tilmicosin (15 mg/kg) on two occasions, 4 days apart - lambs in group C were untreated controls. The lambs were monitored before and after treatment and the clinical findings were scored; they were euthanatised 42 days after treatment for pathological examination of the lungs. Groups were similar at the start of a field trial with respect to all parameters (general clinical condition, presence of nasal discharge, presence of ophthalmic discharge, results of lung auscultation) evaluated (P > 0.05). After treatment, no systemic or local adverse reactions were observed in any lamb. Forty-two days after treatment, the median general clinical assessment score of groups MH, ML3 and T was 0, that of group ML2 was I and that of group C lambs was 2 (P < 0.01). Treatment with marbofloxacin was associated with improved clinical scores; the results were similar for all evaluations 14 days after treatment and subsequently. Clinical cure rate 42 days after treatment was 100, 100, 42, 100 and 0% for group MH, ML3, ML2, T and C lambs, respectively (P < 0.01). After controlling for initial weight, treatment was found to have a significant effect on carcass weight (P < 0.01). Pairwise differences in lung lesion scores between any of the four treated groups and the untreated controls were significant (P < 0.02). It is concluded that marbofloxacin is effective against respiratory infections of lambs at a dose rate of 3.0 mg/kg bodyweight given on two occasions, once daily 2 days apart or at a dose rate of 2.0 mg/kg given on three occasions for three consecutive days. (C) 2006 Elsevier B.V. All rights reserved. | en |
dc.source | Small Ruminant Research | en |
dc.source.uri | <Go to ISI>://WOS:000247946900041 | |
dc.subject | sheep | en |
dc.subject | pneumonia | en |
dc.subject | fluoroquinolones | en |
dc.subject | marbofloxacin | en |
dc.subject | Mannheimia | en |
dc.subject | haemolytica | en |
dc.subject | Mycoplasma | en |
dc.subject | IN-VITRO ACTIVITY | en |
dc.subject | EXPERIMENTAL PASTEURELLOSIS | en |
dc.subject | PHARMACOKINETIC | en |
dc.subject | BEHAVIOR | en |
dc.subject | TILMICOSIN | en |
dc.subject | OXYTETRACYCLINE | en |
dc.subject | DANOFLOXACIN | en |
dc.subject | DISEASE | en |
dc.subject | GOATS | en |
dc.subject | SHEEP | en |
dc.subject | SPECTINOMYCIN | en |
dc.subject | Agriculture, Dairy & Animal Science | en |
dc.title | Efficacy of marbofloxacin against respiratory infections of lambs | en |
dc.type | journalArticle | en |
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