Εμφάνιση απλής εγγραφής

dc.creatorScott, R. A.en
dc.creatorBailey, M. E. S.en
dc.creatorMoran, C. N.en
dc.creatorWilson, R. H.en
dc.creatorFuku, N.en
dc.creatorTanaka, M.en
dc.creatorTsiokanos, A.en
dc.creatorJamurtas, A. Z.en
dc.creatorGrammatikaki, E.en
dc.creatorMoschonis, G.en
dc.creatorManios, Y.en
dc.creatorPitsiladis, Y. P.en
dc.date.accessioned2015-11-23T10:47:07Z
dc.date.available2015-11-23T10:47:07Z
dc.date.issued2010
dc.identifier10.1038/ejhg.2010.131
dc.identifier.issn1018-4813
dc.identifier.urihttp://hdl.handle.net/11615/32939
dc.description.abstractStudies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk. Studies of the interaction between genetic and environmental factors such as physical activity (PA) will promote the understanding of how lifestyle can modulate genetic contributions to obesity. In this study, we investigated the effect of FTO genotype, and interactions with PA or energy intake, in young children and adolescents. In all, 1-5-year-old children from the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS) study (N=1980) and 11-18-year-old Greek adolescents (N=949) were measured for adiposity-related phenotypes and genotyped at the FTO single-nucleotide polymorphism (SNP) marker, rs17817449. Adolescents were classified as physically active or inactive based on self-reported levels of PA. In adolescents, FTO genotype influenced weight (P=0.001) and BMI (P=0.007). There was also a significant SNP*PA*gender interaction (P=0.028) on BMI, which reflected the association between FTO genotype and BMI in males (P=0.016), but not females (P=0.15), and significant SNP*PA interaction in males (P=0.007), but not females (P=0.74). The FTO genotype effect was more pronounced in inactive than active males. Inactive males homozygous for the G allele had a mean BMI 3 kg/m(2) higher than T carriers (P=0.008). In the GENESIS study, no significant association between FTO genotype and adiposity was found. The present findings highlight PA as an important factor modifying the effect of FTO genotype. European Journal of Human Genetics (2010) 18, 1339-1343; doi: 10.1038/ejhg.2010.131; published online 18 August 2010en
dc.sourceEuropean Journal of Human Geneticsen
dc.source.uri<Go to ISI>://WOS:000284376800013
dc.subjectobesityen
dc.subjectFTOen
dc.subjectphysical activityen
dc.subjectBODY-MASS INDEXen
dc.subjectCOMMON VARIANTen
dc.subjectENERGY-INTAKEen
dc.subjectGENETIC-VARIATIONen
dc.subjectADULTen
dc.subjectOBESITYen
dc.subjectLIFE-STYLEen
dc.subjectFAT MASSen
dc.subjectCHILDHOODen
dc.subjectASSOCIATIONen
dc.subjectPOPULATIONen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectGenetics & Heredityen
dc.titleFTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent malesen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής