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Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found

dc.creatorRigopoulou, E. I.en
dc.creatorRoggenbuck, D.en
dc.creatorSmyk, D. S.en
dc.creatorLiaskos, C.en
dc.creatorMytilinaiou, M. G.en
dc.creatorFeist, E.en
dc.creatorConrad, K.en
dc.creatorBogdanos, D. P.en
dc.date.accessioned2015-11-23T10:46:27Z
dc.date.available2015-11-23T10:46:27Z
dc.date.issued2012
dc.identifier10.1016/j.autrev.2012.04.005
dc.identifier.issn1568-9972
dc.identifier.urihttp://hdl.handle.net/11615/32640
dc.description.abstractAsialoglycoprotein receptor (ASGPR) has attracted the attention of liver immunologists for many years. This liver-specific lectin was found to be a major B and T cell autoantigenic target in patients with autoimmune liver diseases, and in particular in autoimmune hepatitis (AIH). This review discusses the biological significance of ASGPR and its relevance to the pathogenesis of autoimmune and virus-triggered liver diseases. We also discuss emerging data on the diagnostic and clinical relevance of anti-ASGPR antibodies in light of recent reports based on commercially available anti-ASGPR enzyme-linked immunosorbent assays. Finally, we critically revisit the data reporting on disease-specific cellular immune responses against ASGPR and their relevance in relation to the pathogenesis of AIH. (C) 2012 Elsevier B.V. All rights reserved.en
dc.source.uri<Go to ISI>://WOS:000313403500024
dc.subjectAutoantibodyen
dc.subjectLiver autoimmunityen
dc.subjectBiomarkeren
dc.subjectAutoimmune hepatitisen
dc.subjectAsialoglycoprotein receptoren
dc.subjectCHRONIC ACTIVE HEPATITISen
dc.subjectPRIMARY BILIARY-CIRRHOSISen
dc.subjectIMMUNOLOGICALen
dc.subjectCROSS-REACTIVITYen
dc.subjectLINKED OLIGOSACCHARIDE UNITSen
dc.subjectMURINEen
dc.subjectMONOCLONAL-ANTIBODIESen
dc.subjectMEMBRANE LIPOPROTEIN LSPen
dc.subjectACID-FREEen
dc.subjectCERULOPLASMINen
dc.subjectREGULATORY T-CELLSen
dc.subjectB-VIRUS-PARTICLESen
dc.subjectSIALIC-ACIDen
dc.subjectImmunologyen
dc.titleAsialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and founden
dc.typejournalArticleen


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