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Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

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Auteur
Pournaras, S.; Ntokou, E.; Zarkotou, O.; Ranellou, K.; Themeli-Digalaki, K.; Stathopoulos, C.; Tsakris, A.
Date
2013
DOI
Sujet
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Résumé
We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 mu g/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
URI
http://hdl.handle.net/11615/32470
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