dc.creator | Pournaras, S. | en |
dc.creator | Kristo, I. | en |
dc.creator | Vrioni, G. | en |
dc.creator | Ikonomidis, A. | en |
dc.creator | Poulou, A. | en |
dc.creator | Petropoulou, D. | en |
dc.creator | Tsakris, A. | en |
dc.date.accessioned | 2015-11-23T10:46:04Z | |
dc.date.available | 2015-11-23T10:46:04Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1128/jcm.02134-09 | |
dc.identifier.issn | 0095-1137 | |
dc.identifier.uri | http://hdl.handle.net/11615/32466 | |
dc.description.abstract | Meropenem heteroresistance was investigated in six apparently meropenem-susceptible, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) clinical isolates, compared with that in carbapenemase-negative, meropenem-susceptible controls. In population analyses, the KPC-KP isolates grew at meropenem concentrations of 64 to 256 mu g/ml. Heteroresistant colonies had significantly elevated expression of the bla(KPC) gene compared with the native populations but did not retain heteroresistance when subcultured in drug-free media. Time-kill assays indicated that meropenem alone was not bactericidal against KPC-KP but efficiently killed the control strains. | en |
dc.source | Journal of Clinical Microbiology | en |
dc.source.uri | <Go to ISI>://WOS:000279318700050 | |
dc.subject | HYDROLYZING BETA-LACTAMASE | en |
dc.subject | PSEUDOMONAS-AERUGINOSA | en |
dc.subject | ESCHERICHIA-COLI | en |
dc.subject | RESISTANT | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | SPREAD | en |
dc.subject | THREAT | en |
dc.subject | KPC-2 | en |
dc.subject | Microbiology | en |
dc.title | Characteristics of Meropenem Heteroresistance in Klebsiella pneumoniae Carbapenemase (KPC)-Producing Clinical Isolates of K-pneumoniae | en |
dc.type | journalArticle | en |