dc.creator | Poulou, M. | en |
dc.creator | Kaliakatsos, M. | en |
dc.creator | Tsezou, A. | en |
dc.creator | Kanavakis, E. | en |
dc.creator | Malizos, K. N. | en |
dc.creator | Tzetis, M. | en |
dc.date.accessioned | 2015-11-23T10:46:00Z | |
dc.date.available | 2015-11-23T10:46:00Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1089/gte.2007.0114 | |
dc.identifier.issn | 1090-6576 | |
dc.identifier.uri | http://hdl.handle.net/11615/32437 | |
dc.description.abstract | Purpose: Osteoarthritis (OA) is characterized by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change, and synovitis. The Calmodulin 1 gene (CALM1) encodes for a ubiquitous eukaryotic Ca2+ binding protein and is the principal mediator of the calcium signal. The protein thus affects the chondrocyte's response to mechanical load. A functional core promoter single nucleotide polymorphism (SNP) -16C/T (rs12885713) was recently associated with hip OA (HOA) in the Japanese population, while no association was found in a British group of patients with HOA. Our objective was to assess whether this SNP was also associated with knee OA (KOA) in a Greek Caucasian population sample. Methods: The -16T/C SNP was genotyped in a 351 case-control cohort-158 patients with idiopathic KOA and 193 controls. Results: No significant differences were found in genotype frequencies for the -16T/C SNP of CALM1 gene between cases and controls (p = 0.581). Conclusion: Our data implied that the -16TT (rs12885713) CALM1 core promoter genotype is not a risk factor for OA etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility. | en |
dc.source.uri | <Go to ISI>://WOS:000256837200015 | |
dc.subject | CAUCASIAN POPULATION | en |
dc.subject | HIP OSTEOARTHRITIS | en |
dc.subject | D-REPEAT | en |
dc.subject | ASPORIN | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | ASPN | en |
dc.subject | Genetics & Heredity | en |
dc.subject | Medicine, Research & Experimental | en |
dc.title | Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin | en |
dc.type | journalArticle | en |