dc.creator | Pitsikas, N. | en |
dc.creator | Boultadakis, A. | en |
dc.creator | Sakellaridis, N. | en |
dc.date.accessioned | 2015-11-23T10:45:42Z | |
dc.date.available | 2015-11-23T10:45:42Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1016/j.neuroscience.2008.04.001 | |
dc.identifier.issn | 0306-4522 | |
dc.identifier.uri | http://hdl.handle.net/11615/32301 | |
dc.description.abstract | There are experimental evidences indicating that the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hyperactivity, stereotypies and ataxia). The present study was designed to investigate the effects of ketamine on rats' non-spatial and spatial recognition memory. For this purpose the object recognition and the object location task were selected. Pre- or post-training systemic administration of ketamine (0.3, 1 and 3 mg/kg; i.p.) in a dose-dependent manner disrupted animals' performance in both these recognition memory paradigms, suggesting that this compound affected pre- and post-training memory components. The current results indicate that the non-competitive NMDA antagonist ketamine may modulate either spatial or non-spatial recognition memory. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved. | en |
dc.source | Neuroscience | en |
dc.source.uri | <Go to ISI>://WOS:000257172200006 | |
dc.subject | ketamine | en |
dc.subject | object recognition | en |
dc.subject | object location | en |
dc.subject | working memory | en |
dc.subject | rat | en |
dc.subject | RECEPTOR ANTAGONIST MK-801 | en |
dc.subject | METHYL-D-ASPARTATE | en |
dc.subject | LONG-TERM-MEMORY | en |
dc.subject | OBJECT | en |
dc.subject | RECOGNITION | en |
dc.subject | NMDA RECEPTOR | en |
dc.subject | PREFRONTAL CORTEX | en |
dc.subject | PHENCYCLIDINE | en |
dc.subject | PERFORMANCE | en |
dc.subject | DOPAMINE | en |
dc.subject | MICE | en |
dc.subject | Neurosciences | en |
dc.title | Effects of sub-anesthetic doses of ketamine on rats' spatial and non-spatial recognition memory | en |
dc.type | journalArticle | en |