dc.creator | Patrinos, G. P. | en |
dc.creator | Samperi, P. | en |
dc.creator | Nigro, L. I. | en |
dc.creator | Kollia, P. | en |
dc.creator | Schiliro, G. | en |
dc.creator | Papadakis, M. N. | en |
dc.date.accessioned | 2015-11-23T10:45:13Z | |
dc.date.available | 2015-11-23T10:45:13Z | |
dc.date.issued | 2005 | |
dc.identifier | 10.1002/ajh.20400 | |
dc.identifier.issn | 3618609 | |
dc.identifier.uri | http://hdl.handle.net/11615/32093 | |
dc.description.abstract | There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the βS/Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the Aγ-499 T→A variation in sickle cell anemia chromosomes of Sicilian and North African origin bearing the βS/Benin haplotype. Being absent from North American βS/Benin chromosomes, which were studied previously, this variation is indicative for the molecular heterogeneity of the βS/Benin haplotype. © 2005 Wiley-Liss, Inc. | en |
dc.source | American Journal of Hematology | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-24344469428&partnerID=40&md5=08d9519ab30a140996a39a9ec81d4f56 | |
dc.subject | βS/Benin haplotype | en |
dc.subject | γ-globin genes | en |
dc.subject | DGGE | en |
dc.subject | Sickle cell anemia | en |
dc.subject | adenine | en |
dc.subject | thymine | en |
dc.subject | article | en |
dc.subject | Asian | en |
dc.subject | chromosome | en |
dc.subject | gene mutation | en |
dc.subject | genetic heterogeneity | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | Italy | en |
dc.subject | major clinical study | en |
dc.subject | North Africa | en |
dc.subject | North America | en |
dc.subject | priority journal | en |
dc.subject | Africa, Northern | en |
dc.subject | Anemia, Sickle Cell | en |
dc.subject | Chromosome Mapping | en |
dc.subject | Globins | en |
dc.subject | Haplotypes | en |
dc.subject | Hemoglobins | en |
dc.subject | Humans | en |
dc.title | Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the βS/benin haplotype | en |
dc.type | journalArticle | en |