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DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs
dc.creator | Paraskevopoulou, M. D. | en |
dc.creator | Georgakilas, G. | en |
dc.creator | Kostoulas, N. | en |
dc.creator | Reczko, M. | en |
dc.creator | Maragkakis, M. | en |
dc.creator | Dalamagas, T. M. | en |
dc.creator | Hatzigeorgiou, A. G. | en |
dc.date.accessioned | 2015-11-23T10:44:56Z | |
dc.date.available | 2015-11-23T10:44:56Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1093/nar/gks1246 | |
dc.identifier.issn | 0305-1048 | |
dc.identifier.uri | http://hdl.handle.net/11615/32033 | |
dc.description.abstract | Recently, the attention of the research community has been focused on long non-coding RNAs (lncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional units are better annotated, databases indexing lncRNA properties and function gradually become essential tools to this process. Aim of DIANA-LncBase (www.microrna.gr/LncBase) is to reinforce researchers' attempts and unravel microRNA (miRNA)-lncRNA putative functional interactions. This study provides, for the first time, a comprehensive annotation of miRNA targets on lncRNAs. DIANA-LncBase hosts transcriptome-wide experimentally verified and computationally predicted miRNA recognition elements (MREs) on human and mouse lncRNAs. The analysis performed includes an integration of most of the available lncRNA resources, relevant high-throughput HITS-CLIP and PAR-CLIP experimental data as well as state-of-the-art in silico target predictions. The experimentally supported entries available in DIANA-LncBase correspond to > 5000 interactions, while the computationally predicted interactions exceed 10 million. DIANA-LncBase hosts detailed information for each miRNA-lncRNA pair, such as external links, graphic plots of transcripts' genomic location, representation of the binding sites, lncRNA tissue expression as well as MREs conservation and prediction scores. | en |
dc.source | Nucleic Acids Research | en |
dc.source.uri | <Go to ISI>://WOS:000312893300033 | |
dc.subject | INTEGRATIVE ANNOTATION | en |
dc.subject | TRANSCRIPTOME | en |
dc.subject | EXPRESSION | en |
dc.subject | DIFFERENTIATION | en |
dc.subject | REVEALS | en |
dc.subject | PROTEIN | en |
dc.subject | SITES | en |
dc.subject | CLIP | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs | en |
dc.type | journalArticle | en |
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