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dc.creatorPapanagiotou, M.en
dc.creatorMalizos, K. N.en
dc.creatorVlychou, M.en
dc.creatorDailiana, Z. H.en
dc.date.accessioned2015-11-23T10:43:49Z
dc.date.available2015-11-23T10:43:49Z
dc.date.issued2014
dc.identifier10.1302/0301-620X.96B1.32773
dc.identifier.issn20494408
dc.identifier.urihttp://hdl.handle.net/11615/31844
dc.description.abstractThis preliminary study evaluates a combination of bone morphogenetic protein (BMP)-7 and non-vascularised autologous fibular grafting (AFG) for the treatment of osteonecrosis of the femoral head. BMP-7/AFG combination was applied in seven pre-collapse femoral heads (five Steinberg stage II, two stage III) in six patients. Pre- and post-operative evaluation included clinical (Harris hip score (HHS), visual analogue scale (VAS) for pain) and radiological assessment (radiographs, quantitative CT) at a mean follow-up of 4 years (2 to 5.5). A marked improvement of function (mean HHS increase of 49.2) and decrease of pain level (mean VAS decrease of 5) as well as retention of the sphericity of the femoral head was noted in five hips at the latest follow-up, while signs of consolidation were apparent from the third post-operative month. One patient (two hips) required bilateral total hip replacement at one year post-operatively. In the series as a whole, quantitative-CT evaluation revealed similar densities between affected and normal bone. Heterotopic ossification was observed in four hips, without compromise of the clinical outcome. In this limited series AFG/BMP-7 combination proved a safe and effective method for the treatment of femoral head osteonecrosis, leading to early consolidation of the AFG and preventing collapse in five of seven hips, while the operative time and post-operative rehabilitation period were much shorter compared with free vascularised fibular grafts. © 2014 The British Editorial Society of Bone & Joint Surgery.en
dc.sourceBone and Joint Journalen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84892579363&partnerID=40&md5=878fcef348c9a9c16073a30276886e73
dc.subjectosteogenic protein 1en
dc.subjectadulten
dc.subjectarticleen
dc.subjectautologous fibular graftingen
dc.subjectbone densityen
dc.subjectbone necrosisen
dc.subjectclinical articleen
dc.subjectclinical assessmenten
dc.subjectcollapseen
dc.subjectcomparative effectivenessen
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectfemur headen
dc.subjectfibula graften
dc.subjectfollow upen
dc.subjectHarris hip scoreen
dc.subjectheterotopic ossificationen
dc.subjecthip painen
dc.subjecthumanen
dc.subjectmaleen
dc.subjectmusculoskeletal functionen
dc.subjectoperation durationen
dc.subjectossificationen
dc.subjectoutcome assessmenten
dc.subjectpostoperative careen
dc.subjectpreoperative evaluationen
dc.subjectpriority journalen
dc.subjectsurgical techniqueen
dc.subjecttotal hip prosthesisen
dc.subjectvisual analog scaleen
dc.subjectX ray filmen
dc.titleAutologous (non-vascularised) fibular grafting with recombinant bone morphogenetic protein-7 for the treatment of femoral head osteonecrosis: Preliminary reporten
dc.typejournalArticleen


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