Εμφάνιση απλής εγγραφής

dc.creatorPapanagiotou, M.en
dc.creatorDailiana, Z. H.en
dc.creatorKarachalios, T.en
dc.creatorVaritimidis, S.en
dc.creatorVlychou, M.en
dc.creatorHantes, M.en
dc.creatorMalizos, K. N.en
dc.date.accessioned2015-11-23T10:43:48Z
dc.date.available2015-11-23T10:43:48Z
dc.date.issued2015
dc.identifier10.1302/0301-620X.97B7.35089
dc.identifier.issn20494394
dc.identifier.urihttp://hdl.handle.net/11615/31842
dc.description.abstractWe report the outcome of 84 nonunions involving long bones which were treated with rhBMP-7, in 84 patients (60 men: 24 women) with a mean age 46 years (18 to 81) between 2003 and 2011. The patients had undergone a mean of three previous operations (one to 11) for nonunion which had been present for a mean of 17 months (4 months to 20 years). The nonunions involved the lower limb in 71 patients and the remainder involved the upper limb. A total of 30 nonunions were septic. Treatment was considered successful when the nonunion healed without additional procedures. The relationship between successful union and the time to union was investigated and various factors including age and gender, the nature of the nonunion (location, size, type, chronicity, previous procedures, infection, the condition of the soft tissues) and type of index procedure (revision of fixation, type of graft, amount of rhBMP-7) were analysed. The improvement of the patients' quality of life was estimated using the Short Form (SF) 12 score. A total of 68 nonunions (80.9%) healed with no need for further procedures at a mean of 5.4 months (3 to 10) post-operatively. Multivariate logistic regression analysis of the factors affecting union suggested that only infection significantly affected the rate of union (p = 0.004).Time to union was only affected by the number of previous failed procedures (p = 0.006). An improvement of 79% and 32.2% in SF-12 physical and mental score, respectively, was noted within the first post-operative year. Rh-BMP-7 combined with bone grafts, enabled healing of the nonunion and improved quality of life in about 80% of patients. Aseptic nonunions were much more likely to unite than septic ones. The number of previous failed operations significantly delayed the time to union. © 2015 The British Editorial Society of Bone & Joint Surgery.en
dc.sourceBone and Joint Journalen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84937555551&partnerID=40&md5=523ca70c01138053ebba8db83854fec7
dc.subjectrecombinant bone morphogenetic proteinen
dc.subjectrecombinant osteogenic protein 7en
dc.subjectunclassified drugen
dc.subjectBMP7 protein, humanen
dc.subjectosteogenic protein 1en
dc.subjectadulten
dc.subjectageden
dc.subjectArticleen
dc.subjectbone transplantationen
dc.subjectcallusen
dc.subjectfemaleen
dc.subjectfracture nonunionen
dc.subjectheterotopic ossificationen
dc.subjecthumanen
dc.subjectlong boneen
dc.subjectlong bone nonunion fractureen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectoutcome assessmenten
dc.subjectperoperative complicationen
dc.subjectpostoperative complicationen
dc.subjectpriority journalen
dc.subjectquality of lifeen
dc.subjectradiological parametersen
dc.subjectrecurrent infectionen
dc.subjectseromaen
dc.subjectShort Form 12en
dc.subjecttreatment responseen
dc.subjectadolescenten
dc.subjectFractures, Boneen
dc.subjectFractures, Ununiteden
dc.subjectgovernmenten
dc.subjectmiddle ageden
dc.subjectmultimodality cancer therapyen
dc.subjectvery elderlyen
dc.subjectyoung adulten
dc.subjectAged, 80 and overen
dc.subjectBone Morphogenetic Protein 7en
dc.subjectCombined Modality Therapyen
dc.subjectHumansen
dc.titleRhBMP-7 for the Treatment of nonunion of fractures of long bonesen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής