Factors Influencing Linezolid-Nonsusceptible Coagulase-Negative Staphylococci Dissemination Among Patients in the Intensive Care Unit: A Retrospective Cohort Study
Auteur
Papadimitriou-Olivgeris, M.; Giormezis, N.; Fligou, F.; Liakopoulos, A.; Marangos, M.; Anastassiou, E. D.; Petinaki, E.; Filos, K. S.; Spiliopoulou, I.Date
2013Sujet
Résumé
Background: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit. Methods: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones. Results: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day. Conclusions: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS. (C) 2014 S. Karger AG, Basel