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Factors Influencing Linezolid-Nonsusceptible Coagulase-Negative Staphylococci Dissemination Among Patients in the Intensive Care Unit: A Retrospective Cohort Study
dc.creator | Papadimitriou-Olivgeris, M. | en |
dc.creator | Giormezis, N. | en |
dc.creator | Fligou, F. | en |
dc.creator | Liakopoulos, A. | en |
dc.creator | Marangos, M. | en |
dc.creator | Anastassiou, E. D. | en |
dc.creator | Petinaki, E. | en |
dc.creator | Filos, K. S. | en |
dc.creator | Spiliopoulou, I. | en |
dc.date.accessioned | 2015-11-23T10:43:04Z | |
dc.date.available | 2015-11-23T10:43:04Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1159/000363281 | |
dc.identifier.issn | 0009-3157 | |
dc.identifier.uri | http://hdl.handle.net/11615/31707 | |
dc.description.abstract | Background: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit. Methods: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones. Results: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day. Conclusions: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS. (C) 2014 S. Karger AG, Basel | en |
dc.source.uri | <Go to ISI>://WOS:000341818900005 | |
dc.subject | Coagulase-negative staphylococci | en |
dc.subject | Linezolid | en |
dc.subject | Resistance | en |
dc.subject | Clones | en |
dc.subject | Intensive care unit | en |
dc.subject | Risk factors | en |
dc.subject | RESISTANT STAPHYLOCOCCUS | en |
dc.subject | EPIDERMIDIS | en |
dc.subject | INFECTION | en |
dc.subject | COLONIZATION | en |
dc.subject | ENTEROCOCCUS | en |
dc.subject | CRITERIA | en |
dc.subject | PROFILE | en |
dc.subject | COHNII | en |
dc.subject | GREECE | en |
dc.subject | STATES | en |
dc.subject | Oncology | en |
dc.subject | Pharmacology & Pharmacy | en |
dc.title | Factors Influencing Linezolid-Nonsusceptible Coagulase-Negative Staphylococci Dissemination Among Patients in the Intensive Care Unit: A Retrospective Cohort Study | en |
dc.type | journalArticle | en |
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