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  •   University of Thessaly Institutional Repository
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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
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Early Major Worsening in Ischemic Stroke: Predictors and Outcome

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Author
Ntaios, G.; Lambrou, D.; Cuendet, D.; Michel, P.
Date
2013
DOI
10.1007/s12028-013-9865-7
Keyword
Worsening
Stroke
Acute phase
Cervical artery dissection
Hemorrhagic
transformation
EARLY NEUROLOGICAL DETERIORATION
PLASMINOGEN-ACTIVATOR
THROMBOLYTIC
THERAPY
TRIAL
PROGRESSION
PROGNOSIS
PATTERN
Critical Care Medicine
Clinical Neurology
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Abstract
We aimed to investigate the characteristics and outcome of patients suffering early major worsening (EMW) after acute ischemic stroke (AIS) and assess the parameters associated with it. All consecutive patients with AIS in the ASTRAL registry until 10/2010 were included. EMW was defined as an NIHSS increase of a parts per thousand yen8 points within the first 24 h after admission. The Bootstrap version of the Kolmogorov-Smirnov test and the chi (2)-test were used for the comparison of continuous and categorical covariates, respectively, between patients with and without EMW. Multiple logistic regression analysis was performed to identify independent predictors of EMW. Among 2155 patients, 43 (2.0 %) had an EMW. EMW was independently associated with hemorrhagic transformation (OR 22.6, 95 % CI 9.4-54.2), cervical artery dissection (OR 9.5, 95 % CI 4.4-20.6), initial dysarthria (OR 3.7, 95 % CI 1.7-8.0), and intravenous thrombolysis (OR 2.1, 95 % CI 1.1-4.3), whereas a negative association was identified with initial eye deviation (OR 0.4, 95 % CI 0.2-0.9). Favorable outcome at 3 and 12 months was less frequent in patients with EMW compared to patients without (11.6 vs. 55.3 % and 16.3 vs. 50.7 %, respectively), and case fatality was higher (53.5 vs. 12.9 % and 55.8 vs. 16.8 %, respectively). Stroke recurrence within 3 months in surviving patients was similar between patients with and without EMW (9.3 vs. 9.0 %, respectively). Worsening of a parts per thousand yen8 points in the NIHSS score during the first 24 h in AIS patients is related to cervical artery dissection and hemorrhagic transformation. It justifies urgent repeat parenchymal and arterial imaging. Both conditions may be influenced by targeted interventions in the acute phase of stroke.
URI
http://hdl.handle.net/11615/31433
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19674]
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ΕΣΠΑ 2007-2013
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Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
Ψηφιακή Ελλάδα
ΕΣΠΑ 2007-2013
Με τη συγχρηματοδότηση της Ελλάδας και της Ευρωπαϊκής Ένωσης
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