dc.creator | Nomikos, I. | en |
dc.creator | Kalogerakos, K. | en |
dc.creator | Athanasiou, E. | en |
dc.creator | Plakokefales, E. | en |
dc.creator | Sioutopoulou, D. | en |
dc.creator | Satra, M. | en |
dc.creator | Vamvakopoulos, N. C. | en |
dc.date.accessioned | 2015-11-23T10:41:19Z | |
dc.date.available | 2015-11-23T10:41:19Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1055/s-2008-1062711 | |
dc.identifier.issn | 0947-7349 | |
dc.identifier.uri | http://hdl.handle.net/11615/31414 | |
dc.description.abstract | Objective: Study the role of hyperglycemia-induced beta cell loss on grafted islet destruction. Design: Male inbred rats were made diabetic by streptozotocin administration and used as islet donors and/or isograft recipients to probe directly the role of hyperglycemia as an important determinant of transplanted islet fate, following exclusion of immune-related causes of islet graft destruction like allograft immunity and disease recurrence. Results: Our studies showed that: a) Hyperglycemia destroyed islet but not pituitary isografts and b) Tight control of normoglycemia by sufficient islet mass engraftment prevented graft damage. Conclusion: While sustained hyperglycemia caused destruction of transplanted islet isografts, induction of normoglycemia by transplantation of sufficient islet mass to diabetic recipients had a beneficial long term effect on their functional engraftment. | en |
dc.source | Experimental and Clinical Endocrinology & Diabetes | en |
dc.source.uri | <Go to ISI>://WOS:000260561900009 | |
dc.subject | glucose metabolism | en |
dc.subject | pancreas | en |
dc.subject | insulin | en |
dc.subject | islet transplantation | en |
dc.subject | DIABETIC-RATS | en |
dc.subject | TERM | en |
dc.subject | TISSUE | en |
dc.subject | MICE | en |
dc.subject | MASS | en |
dc.subject | Endocrinology & Metabolism | en |
dc.title | Role of Hyperglycemia in Isogeneic Islet Transplantation: An Experimental Animal Study | en |
dc.type | journalArticle | en |