Cytokine gene polymorphisms in multiple sclerosis: a meta-analysis of 45 studies including 7379 cases and 8131 controls
dc.creator | Nikolopoulos, G. K. | en |
dc.creator | Masgala, A. | en |
dc.creator | Tsiara, C. | en |
dc.creator | Limitsiou, O. K. | en |
dc.creator | Karnaouri, A. C. | en |
dc.creator | Dimou, N. L. | en |
dc.creator | Bagos, P. G. | en |
dc.date.accessioned | 2015-11-23T10:41:13Z | |
dc.date.available | 2015-11-23T10:41:13Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1111/j.1468-1331.2011.03355.x | |
dc.identifier.issn | 1351-5101 | |
dc.identifier.uri | http://hdl.handle.net/11615/31398 | |
dc.description.abstract | Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the potential association between various cytokine gene polymorphisms and the occurrence of multiple sclerosis. A comprehensive literature search yielded 45 eligible studies, which involved 7379 cases and 8131 controls. Totally, the effect of eight polymorphisms, i.e. IL-1A C[-889] T, IL-1B C[-511] T, IL-1B C[3953] T, IL-4 C[33] T, IL-10 C[-819] T, IL-10 G[-1082]A, tumour necrosis factor-a (TNFA) G[-308]A and TNFA G[-238]A, was evaluated in a random-effects meta-analysis. There was no evidence of statistically significant association between the aforementioned polymorphisms and multiple sclerosis. Publication bias and heterogeneity were absent in most analyses. Within its limitations, the current literature-based meta-analysis does not indicate that specific polymorphic variations of genes encoding pro-inflammatory and anti-inflammatory cytokines affect susceptibility to multiple sclerosis. | en |
dc.source.uri | <Go to ISI>://WOS:000292084800009 | |
dc.subject | cytokines | en |
dc.subject | interleukin | en |
dc.subject | meta-analysis | en |
dc.subject | multiple sclerosis | en |
dc.subject | single-nucleotide polymorphism | en |
dc.subject | tumour necrosis factor | en |
dc.subject | TUMOR-NECROSIS-FACTOR | en |
dc.subject | RECEPTOR ANTAGONIST GENES | en |
dc.subject | ENVIRONMENTAL | en |
dc.subject | RISK-FACTORS | en |
dc.subject | FACTOR-ALPHA | en |
dc.subject | TNF-ALPHA | en |
dc.subject | PROMOTER POLYMORPHISMS | en |
dc.subject | JAPANESE | en |
dc.subject | PATIENTS | en |
dc.subject | DISEASE SEVERITY | en |
dc.subject | PUBLICATION BIAS | en |
dc.subject | IRANIAN PATIENTS | en |
dc.subject | Clinical Neurology | en |
dc.subject | Neurosciences | en |
dc.title | Cytokine gene polymorphisms in multiple sclerosis: a meta-analysis of 45 studies including 7379 cases and 8131 controls | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |