dc.creator | Nakajima, M. | en |
dc.creator | Takahashi, A. | en |
dc.creator | Kou, I. | en |
dc.creator | Rodriguez-Fontenla, C. | en |
dc.creator | Gomez-Reino, J. J. | en |
dc.creator | Furuichi, T. | en |
dc.creator | Dai, J. | en |
dc.creator | Sudo, A. | en |
dc.creator | Uchida, A. | en |
dc.creator | Fukui, N. | en |
dc.creator | Kubo, M. | en |
dc.creator | Kamatani, N. | en |
dc.creator | Tsunoda, T. | en |
dc.creator | Malizos, K. N. | en |
dc.creator | Tsezou, A. | en |
dc.creator | Gonzalez, A. | en |
dc.creator | Nakamura, Y. | en |
dc.creator | Ikegawa, S. | en |
dc.date.accessioned | 2015-11-23T10:40:26Z | |
dc.date.available | 2015-11-23T10:40:26Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1371/journal.pone.0009723 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11615/31261 | |
dc.description.abstract | Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of similar to 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA. | en |
dc.source | Plos One | en |
dc.source.uri | <Go to ISI>://WOS:000276456300012 | |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISM | en |
dc.subject | INCREASES SUSCEPTIBILITY | en |
dc.subject | ARTICULAR | en |
dc.subject | CHONDROCYTES | en |
dc.subject | OSTEO-ARTHRITIS | en |
dc.subject | GENE | en |
dc.subject | JAPANESE | en |
dc.subject | PHENOTYPES | en |
dc.subject | ANTIGENS | en |
dc.subject | HLA-DQA2 | en |
dc.subject | BTNL2 | en |
dc.subject | Multidisciplinary Sciences | en |
dc.title | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study | en |
dc.type | journalArticle | en |