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New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study

dc.creatorNakajima, M.en
dc.creatorTakahashi, A.en
dc.creatorKou, I.en
dc.creatorRodriguez-Fontenla, C.en
dc.creatorGomez-Reino, J. J.en
dc.creatorFuruichi, T.en
dc.creatorDai, J.en
dc.creatorSudo, A.en
dc.creatorUchida, A.en
dc.creatorFukui, N.en
dc.creatorKubo, M.en
dc.creatorKamatani, N.en
dc.creatorTsunoda, T.en
dc.creatorMalizos, K. N.en
dc.creatorTsezou, A.en
dc.creatorGonzalez, A.en
dc.creatorNakamura, Y.en
dc.creatorIkegawa, S.en
dc.date.accessioned2015-11-23T10:40:26Z
dc.date.available2015-11-23T10:40:26Z
dc.date.issued2010
dc.identifier10.1371/journal.pone.0009723
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11615/31261
dc.description.abstractOsteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of similar to 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.en
dc.sourcePlos Oneen
dc.source.uri<Go to ISI>://WOS:000276456300012
dc.subjectSINGLE-NUCLEOTIDE POLYMORPHISMen
dc.subjectINCREASES SUSCEPTIBILITYen
dc.subjectARTICULARen
dc.subjectCHONDROCYTESen
dc.subjectOSTEO-ARTHRITISen
dc.subjectGENEen
dc.subjectJAPANESEen
dc.subjectPHENOTYPESen
dc.subjectANTIGENSen
dc.subjectHLA-DQA2en
dc.subjectBTNL2en
dc.subjectMultidisciplinary Sciencesen
dc.titleNew Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Studyen
dc.typejournalArticleen


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