dc.creator | Moran, C. N. | en |
dc.creator | Vassilopoulos, C. | en |
dc.creator | Tsiokanos, A. | en |
dc.creator | Jamurtas, A. Z. | en |
dc.creator | Bailey, M. E. S. | en |
dc.creator | Montgomery, H. E. | en |
dc.creator | Wilson, R. H. | en |
dc.creator | Pitsiladis, Y. P. | en |
dc.date.accessioned | 2015-11-23T10:39:51Z | |
dc.date.available | 2015-11-23T10:39:51Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1038/sj.ejhg.5201550 | |
dc.identifier.issn | 1018-4813 | |
dc.identifier.uri | http://hdl.handle.net/11615/31115 | |
dc.description.abstract | Genetic variation in the human Angiotensin I-Converting Enzyme ( ACE) gene has been associated with many heritable traits, including physical performance. Herein we report the results of a study of several physical, physiological and skill parameters and lifestyle in 1027 teenage Greeks. We show that there is a strong association (P < 0.001) between the ACE I/D (insertion/deletion) polymorphism and both handgrip strength and vertical jump in females, homozygotes for the I-allele exhibiting higher performance-related phenotype scores, accounting for up to 4.5% of the phenotypic variance. The association is best explained by a model in which the D-allele is dominant, with the mean phenotypic value in the I/D heterozygotes being close to that of the mean of the DD homozygotes. The association acts across the phenotype distribution in a classical polygenic manner. Other polymorphisms that define major ACE haplotypes in European populations (rs4424958, rs4311) show weaker associations with these performance-related phenotypes than does I/D. Similarly, diplotypes defined by these polymorphisms do not explain significantly larger amounts of the variance than I/D alone. As ACE I/D is the polymorphism most strongly associated with circulating ACE activity in European populations, we propose that the functional allelic differences that influence ACE activity also mediate the associations with the performance-related phenotypes studied here. | en |
dc.source.uri | <Go to ISI>://WOS:000235499300014 | |
dc.subject | angiotensin I-converting enzyme | en |
dc.subject | I/D polymorphism | en |
dc.subject | physical performance | en |
dc.subject | haplotype | en |
dc.subject | adolescents | en |
dc.subject | caucasians | en |
dc.subject | ANGIOTENSIN-CONVERTING-ENZYME | en |
dc.subject | HORMONE REPLACEMENT THERAPY | en |
dc.subject | ENDURANCE | en |
dc.subject | ATHLETE STATUS | en |
dc.subject | SHUTTLE RUN TEST | en |
dc.subject | GENE POLYMORPHISM | en |
dc.subject | NO ASSOCIATION | en |
dc.subject | 2003 UPDATE | en |
dc.subject | PERFORMANCE | en |
dc.subject | GENOTYPE | en |
dc.subject | FITNESS | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.subject | Genetics & Heredity | en |
dc.title | The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents | en |
dc.type | journalArticle | en |