Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study
dc.creator | Mollaki, V. | en |
dc.creator | Georgiadis, T. | en |
dc.creator | Tassidou, A. | en |
dc.creator | Ioannou, M. | en |
dc.creator | Daniil, Z. | en |
dc.creator | Koutsokera, A. | en |
dc.creator | Papathanassiou, A. A. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Vassilopoulos, G. | en |
dc.date.accessioned | 2015-11-23T10:39:49Z | |
dc.date.available | 2015-11-23T10:39:49Z | |
dc.date.issued | 2009 | |
dc.identifier | 10.1038/jhg.2009.90 | |
dc.identifier.issn | 1434-5161 | |
dc.identifier.uri | http://hdl.handle.net/11615/31102 | |
dc.description.abstract | Toll-like receptors (TLRs) and myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms may be involved in the pathogenesis of Hodgkin's lymphoma (HL) through altered immunoregulatory and inflammatory responses. A candidate-gene association study was conducted to investigate the association between TLR9 -1237T > C, TLR9 2848A > G, MYD88 -938C > A and MYD88 1944C > G gene polymorphisms and the risk for HL. The impact of haplotypes was also examined. The study showed that carriership for -1237C and 2848A was associated with an increased risk for HL (odds ratio (OR)=2.53 (1.36-4.71) and OR=6.20 (1.3-28.8)). The MYD88 polymorphisms produced nonsignificant results. The estimated frequencies of the TLR9/1237C-2848A and MYD88/938C-1944G haplotypes were also significantly different between HL and controls (P < 0.01). In addition, a significant difference between HL and controls was observed for the TLR9/1237C-TLR9/2848A-MYD88/938C-MYD88/1944C haplotypes (P < 0.01). In conclusion, our study showed that TLR polymorphisms, and TLR9 and MYD88 haplotypes are related to the development of HL. Journal of Human Genetics (2009) 54, 655 - 659; doi:10.1038/jhg.2009.90; published online 11 September 2009 | en |
dc.source.uri | <Go to ISI>://WOS:000272381800007 | |
dc.subject | gene | en |
dc.subject | Hodgkin's lymphoma | en |
dc.subject | HL | en |
dc.subject | MYD88 | en |
dc.subject | polymorphism | en |
dc.subject | TLR9 | en |
dc.subject | TOLL-LIKE RECEPTORS | en |
dc.subject | SINGLE-NUCLEOTIDE POLYMORPHISMS | en |
dc.subject | INFECTIOUS-MONONUCLEOSIS | en |
dc.subject | DISEASE | en |
dc.subject | RISK | en |
dc.subject | EXPRESSION | en |
dc.subject | RELATIVES | en |
dc.subject | IMMUNITY | en |
dc.subject | CANCERS | en |
dc.subject | INNATE | en |
dc.subject | Genetics & Heredity | en |
dc.title | Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study | en |
dc.type | journalArticle | en |
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