dc.creator | Minas, M. | en |
dc.creator | Mystridou, P. | en |
dc.creator | Georgoulias, P. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Kostikas, K. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.date.accessioned | 2015-11-23T10:39:41Z | |
dc.date.available | 2015-11-23T10:39:41Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.3109/15412555.2012.727922 | |
dc.identifier.issn | 1541-2555 | |
dc.identifier.uri | http://hdl.handle.net/11615/31043 | |
dc.description.abstract | Fetuin-A is a liver protein that may serve as an inhibitor of systemic inflammation in humans. In the present study we assessed the levels of fetuin-A in COPD patients in stable condition and on exacerbation in an attempt to evaluate it as a clinically relevant biomarker that may serve as predictor of exacerbations of COPD (ECOPD). One hundred COPD outpatients (GOLD stage I to IV) were enrolled in a tertiary University hospital and were submitted to a detailed evaluation, including pulmonary function testing, exercise capacity, quality of life and evaluation of the presence of metabolic syndrome and serum CRP. All patients were followed-up for 1 year, and 36 were re-evaluated at the onset of an ECOPD. Forty otherwise healthy smokers served as controls. Serum fetuin-A levels were reproducible at baseline, 6 and 12 months. COPD patients presented lower levels of fetuin compared to controls [394.5 (321.8-419.6) vs. 487.3 (441.0-548.0) mg/L, p < 0.001]. COPD patients with GOLD stage IV had lower fetuin-A levels compared to stages I-II and III (p < 0.05). Fetuin-A was significantly reduced at the onset of an ECOPD compared to baseline (p < 0.001) and the time to the first ECOPD significantly different between patients with high and low levels of fetuin-A [HR 2.163 (95% CI 1.104-4.238), p = 0.024). The results of the present study suggest that fetuin-A is a reproducible and clinically relevant biomarker in patients with COPD that may be useful in the identification of exacerbation-prone patients. | en |
dc.source.uri | <Go to ISI>://WOS:000314942900005 | |
dc.subject | Fetuin-A | en |
dc.subject | COPD | en |
dc.subject | Biomarker | en |
dc.subject | Systemic inflammation | en |
dc.subject | Exacerbation | en |
dc.subject | OBSTRUCTIVE PULMONARY-DISEASE | en |
dc.subject | C-REACTIVE PROTEIN | en |
dc.subject | BODY-MASS INDEX | en |
dc.subject | SYSTEMIC INFLAMMATION | en |
dc.subject | METABOLIC SYNDROME | en |
dc.subject | MYOCARDIAL-INFARCTION | en |
dc.subject | PREDICTOR | en |
dc.subject | MORTALITY | en |
dc.subject | RECOVERY | en |
dc.subject | DYSPNEA | en |
dc.subject | Respiratory System | en |
dc.title | Fetuin-A is Associated with Disease Severity and Exacerbation Frequency in Patients with COPD | en |
dc.type | journalArticle | en |